ArticleNeuropsychiatric disease and treatment2017
Effects of subthalamic nucleus deep brain stimulation on emotional working memory capacity and mood in patients with Parkinson's disease.
Article in Neuropsychiatric disease and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease: A Meta-Analysis of Mood Effects.Neuropsychology review · 2021Pooled it
- Effects of Deep Brain Stimulation in the Subthalamic Nucleus on Neurocognitive Function in Patients With Parkinson's Disease Compared With Medical Therapy: A Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Sweet spot mapping and structural connectivity in subthalamic stimulation: predicting neuropsychiatric outcomes in Parkinson's disease.Frontiers in neuroscience · 2025Article
- Alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance.Frontiers in behavioral neuroscience · 2023Review
- Semi-automated approaches to optimize deep brain stimulation parameters in Parkinson's disease.Journal of neuroengineering and rehabilitation · 2021Article
- The Role of the Subthalamic Nucleus in Sequential Working Memory in De Novo Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Closed-Loop neuromodulation for clustering neuronal populations.Journal of neurophysiology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Parkinson's disease (PD), cognitive symptoms and mood changes may be even more distressing for the patient than motor symptoms.
objectiveOur aim was to determine the effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on working memory (WM) and mood.
methodsSixteen patients with PD were assessed with STN-DBS switched on (DBS-ON) and with dopaminergic treatment (Med-ON) compared to switched off (DBS-OFF) and without dopaminergic treatment (Med-OFF). The primary outcome measures were a Visual Analog Mood Scale (VAMS) and an emotional 2-back WM task at 12 months after DBS in the optimal DBS-ON/Med-ON setting compared to DBS-OFF/Med-OFF.
resultsComparison of DBS-OFF/Med-OFF to DBS-ON/Med-ON revealed a significant increase in alertness (mean
conclusionIn line with previous studies, we found that patients rated themselves subjectively as more alert, content, and less sedated during short-term DBS-ON. Accuracy in the WM task increased with the combination of DBS and medication, possibly related to higher alertness of the patients. Our results add to the currently mixed results described for DBS on WM and suggest that there are no deleterious DBS effects on this specific cognitive domain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.