ArticleDrug design, development and therapy2017
Comparison of posttransplant outcomes in patients with no, acute, or chronic amiodarone use before heart transplantation.
Article in Drug design, development and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Early Pacemaker Dependency After Heart Transplantation Is Associated with Permanent Pacemaker Implantation, Graft Failure and Mortality.Journal of cardiovascular development and disease · 2024Article
- Five-year results of heart rate control with ivabradine or metoprolol succinate in patients after heart transplantation.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Article
- Pre-transplant Type 2 Diabetes Mellitus Is Associated With Higher Graft Failure and Increased 5-Year Mortality After Heart Transplantation.Frontiers in cardiovascular medicine · 2022Article
- Risk Factors, Treatment and Prognosis of Patients with Lung Cancer after Heart Transplantation.Life (Basel, Switzerland) · 2021Article
- Acute amiodarone pulmonary toxicity in the form of organizing pneumonia triggered by orthotopic heart transplantation.Respiratory medicine case reports · 2021Article
- Combined amiodarone and digitalis therapy before heart transplantation is associated with increased post-transplant mortality.ESC heart failure · 2020Article
- Elevated pre-transplant pulmonary vascular resistance is associated with early post-transplant atrial fibrillation and mortality.ESC heart failure · 2020Observational
- Risk factors and survival of patients with permanent pacemaker implantation after heart transplantation.Journal of thoracic disease · 2019Article
- Analysis of computed tomography density of liver before and after amiodarone administration.Japanese journal of radiology · 2018Article
- Control of cardiac chronotropic function in patients after heart transplantation: effects of ivabradine and metoprolol succinate on resting heart rate in the denervated heart.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Observational
- COPD in patients after heart transplantation is associated with a prolonged hospital stay, early posttransplant atrial fibrillation, and impaired posttransplant survival.Clinical epidemiology · 2018Article
- Chronic digitalis therapy in patients before heart transplantation is an independent risk factor for increased posttransplant mortality.Therapeutics and clinical risk management · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMajor concerns about the safety of pretransplant amiodarone use have been raised. As a result of its long half-life, the cardiac allograft is exposed to amiodarone posing potential risks such as bradycardia, requirement for pacemaker implantation, or increased mortality after heart transplantation (HTX).
objectiveThe aim of this study is to investigate the posttransplant outcomes of patients with no, acute, or chronic amiodarone use before HTX.
methodsThis retrospective single-center study included 530 adult patients who received HTX between 06/1989 and 12/2012. Patients were stratified by their amiodarone therapy before HTX: no continuous amiodarone use (≤90 days before HTX), acute amiodarone use (≤90 days before HTX), and chronic amiodarone use (>90 days before HTX). Differences between the 3 groups in demographics, posttransplant medication, echocardiographic features, heart rates including occurrences of bradycardia, permanent pacemaker implantation, atrial fibrillation (AF), and survival were analyzed.
resultsA total of 412 patients (77.7%) were in the "no amiodarone" group, 23 patients (4.4%) in the "acute amiodarone" group, and 95 patients (17.9%) in the "chronic amiodarone" group. Left ventricular ejection fraction (
conclusionAdministration of acute or chronic pretransplant amiodarone was not related to an increased occurrence of bradycardia, requirement for permanent pacemaker implantation, or mortality after HTX. Importantly, chronic amiodarone use effectively reduced early AF after HTX, whereas acute amiodarone use showed no such effect.
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