Evidence map›Paper›PMID 28684792›Full record

ArticleScientific reports2017

Fungus-derived hydroxyl radicals kill hepatic cells by enhancing nuclear transglutaminase.

Ronak Shrestha, Rajan Shrestha, Xian-Yang Qin, Ting-Fang Kuo, Yugo Oshima, Shun Iwatani, Ryutaro Teraoka, Keisuke Fujii, Mitsuko Hara, Mengqian Li and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Fungal Reactive Oxygen Species Secreted byJournal of fungi (Basel, Switzerland) · 2026
    Article
  3. A Putative NADPH Oxidase Gene in Unicellular PathogenicJournal of fungi (Basel, Switzerland) · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Ronak ShresthaMicro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Saitama, Japan.
Rajan ShresthaMicro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Saitama, Japan.
Xian-Yang QinMicro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Saitama, Japan.
Ting-Fang KuoMicro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Saitama, Japan.
Yugo OshimaCondensed Molecular Materials Laboratory, RIKEN, Wako, Saitama, Japan.ORCID 0000-0001-9822-8262
Shun IwataniSchool of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan.
Ryutaro TeraokaMicro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Saitama, Japan.
Keisuke FujiiSchool of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan.
Mitsuko HaraMicro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Saitama, Japan.
Mengqian LiMicro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Saitama, Japan.
Azusa Takahashi-NakaguchiMedical Mycology Research Center, Chiba University, Chiba, Chiba, Japan.
Hiroji ChibanaMedical Mycology Research Center, Chiba University, Chiba, Chiba, Japan.
Jun LuChina National Research Institute of Food and Fermentation Industries, Beijing, China.
Muyi CaiChina National Research Institute of Food and Fermentation Industries, Beijing, China.
Susumu KajiwaraSchool of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan. skajiwar@bio.titech.ac.jp.
Soichi KojimaMicro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Wako, Saitama, Japan. skojima@riken.jp.ORCID 0000-0002-5252-1612
RIKEN · JPTokyo Institute of Technology · JPChiba University Hospital · JPChina National Research Institute of Food and Fermentation · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously reported the importance of induced nuclear transglutaminase (TG) 2 activity, which results in hepatic cell death, in ethanol-induced liver injury. Here, we show that co-incubation of either human hepatic cells or mouse primary hepatocytes derived from wild-type but not TG2

Indexed as

AcetylcysteineAnimalsCandida albicansCandida glabrataCandidiasisCell DeathCell LineCell NucleusFree Radical ScavengersFungal ProteinsGene DeletionGene Expression RegulationGTP-Binding ProteinsHepatocytesHost-Pathogen InteractionsHumansAcetylcysteineFree Radical ScavengersFungal ProteinsGTP-Binding ProteinsHydroxyl RadicalNADPH OxidasesPeptidesProtein Glutamine gamma Glutamyltransferase 2Transglutaminases

Identifiers

PMID28684792
PMCPMC5500562
OpenAlexW2729753755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.