ArticleScientific reports2017
Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 142 citations in OpenAlex.
- Lumen imaging in calcified coronary arteries using high-resolution Gd-enhanced color K-edge imaging with spectral photon-counting CT: a phantom study.European radiology experimental · 2026Article
- An in silico evaluation of signal and separability properties of k-edge materials in spectral CT.Scientific reports · 2026Article
- Advanced X-Ray Imaging Technology.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Drug-Eluting, Radiopaque, Tumor-Casting Hydrogels for Endovascular Locoregional Therapy of Hepatocellular Carcinoma.bioRxiv : the preprint server for biology · 2025Article
- Neuroimaging with photon-counting computed tomography: A review of clinical applications.World journal of radiology · 2025Review
- CT material decomposition with contrast agents: Single or multiple spectral photon-counting CT scans? A simulation study.Medical physics · 2025Article
- The Emergence of Nanotechnology in the Prognosis and Treatment of Myocardial Infarctions.Recent patents on nanotechnology · 2025Review
- Contrast-to-noise ratio comparison between X-ray fluorescence emission tomography and computed tomography.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Targeted K-Edge Nanoprobes From Praseodymium and Hafnium for Ratiometric Tracking of Dual Biomarkers using Spectral Photon Counting CT.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Technical principles, benefits, challenges, and applications of photon counting computed tomography in coronary imaging: a narrative review.Cardiovascular diagnosis and therapy · 2024Review
- Spectral Photon-Counting Computed Tomography: Technical Principles and Applications in the Assessment of Cardiovascular Diseases.Journal of clinical medicine · 2024Review
- Photon-counting computed tomography in radiology.Polish journal of radiology · 2024Review
- Leveraging 3D Bioprinting and Photon-Counting Computed Tomography to Enable Noninvasive Quantitative Tracking of Multifunctional Tissue Engineered Constructs.Advanced healthcare materials · 2023Article
- Clinical Applications of Photon-counting CT: A Review of Pioneer Studies and a Glimpse into the Future.Radiology · 2023Review
- Cardiovascular Applications of Photon-Counting CT Technology: A Revolutionary New Diagnostic Step.Journal of cardiovascular development and disease · 2023Review
- Clinical applications of photon counting detector CT.European radiology · 2023Review
- Dual-Source Photon-Counting Computed Tomography-Part III: Clinical Overview of Vascular Applications beyond Cardiac and Neuro Imaging.Journal of clinical medicine · 2023Review
- Dual Source Photon-Counting Computed Tomography-Part II: Clinical Overview of Neurovascular Applications.Journal of clinical medicine · 2023Review
- Photon-Counting Computed Tomography (PCCT): Technical Background and Cardio-Vascular Applications.Diagnostics (Basel, Switzerland) · 2023Review
- Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
Abstract
A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet been demonstrated with such a system. We investigated the feasibility of using this system to distinguish gold nanoparticles (AuNP) and an iodinated contrast agent. The contrast agents and calcium phosphate were imaged in phantoms. Conventional CT, gold K-edge, iodine and water images were produced and demonstrated accurate discrimination and quantification of gold and iodine concentrations in a phantom containing mixtures of the contrast agents. In vivo experiments were performed using New Zealand White rabbits at several times points after injections of AuNP and iodinated contrast agents. We found that the contrast material maps clearly differentiated the distributions of gold and iodine in the tissues allowing quantification of the contrast agents' concentrations, which matched their expected pharmacokinetics. Furthermore, rapid, repetitive scanning was done, which allowed measurement of contrast agent kinetics with high temporal resolution. In conclusion, a clinical scale, high count rate SPCCT system is able to discriminate gold and iodine contrast media in different organs in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.