ArticleScientific reports2017
Mie scatter spectra-based device for instant, contact-free, and specific diagnosis of bacterial skin infection.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Rapid enrichment and SERS differentiation of various bacteria in skin interstitial fluid by 4-MPBA-AuNPs-functionalized hydrogel microneedles.Journal of pharmaceutical analysis · 2025Article
- Global burden of bacterial skin diseases from 1990 to 2045: an analysis based on global burden disease data.Archives of dermatological research · 2025Article
- Paper-based sensors for bacteria detection.Nature reviews bioengineering · 2023Review
- Machine learning classification of bacterial species using mix-and-match reagents on paper microfluidic chips and smartphone-based capillary flow analysis.Analytical and bioanalytical chemistry · 2022Article
- Label-free Mie Scattering Identification of Tumor Tissue Using an Angular Photodiode Array.IEEE sensors letters · 2020Article
- Interfacial Effect-Based Quantification of Droplet Isothermal Nucleic Acid Amplification for Bacterial Infection.Scientific reports · 2019Article
- Angular photodiode array-based device to detect bacterial pathogens in a wound model.IEEE sensors journal · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Rapid and specific diagnostic techniques are needed to expedite specific treatment of bacterial skin infections with narrow-spectrum antibiotics, rather than broad-spectrum. Through this work a device was developed to determine the presence of and species responsible for a bacterial skin infection using differences in Mie scatter spectra created by different bacterial species. A 650 nm LED at five different incident angles is used to illuminate the tissue, with Mie scatter being detected by PIN photodiodes at eight different detection angles. Mie scatter patterns are collected at all photodiode angles for each of the incident light angles, resulting in a Mie scatter spectra. Detectable differences in Mie scatter spectra were found using the device developed between commensal bacteria (no infection) and bacteria inoculated (infection) on the surface of both porcine and human cadaveric epidermis. Detectable differences were found between species of infection, specifically Escherichia coli and Staphylococcus aureus, with differences summarized through principle component analysis. Mie scatter spectra can be detected within a few seconds without skin contact. This device is the first to rapidly and specifically diagnose bacterial skin infections in a contact-less manner, allowing for initial treatment with narrow spectrum antibiotics, and helping to reduce the likelihood of resistance.
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Registered trials
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