ArticleJournal of the American Heart Association2017
Association of Proteinuria and Incident Atrial Fibrillation in Patients With Intact and Reduced Kidney Function.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- High-intensity interval training in children and adolescents with special educational needs: a systematic review and narrative synthesis.The international journal of behavioral nutrition and physical activity · 2023Pooled it
- Costs and Healthcare Resource Use Associated with Risk of Cardiovascular Morbidity in Patients with Chronic Kidney Disease: Evidence from a Systematic Literature Review.Advances in therapy · 2021Pooled it
- Association of Albuminuria With 1-Year Risk of Heart Failure and Other Adverse Outcomes in Atrial Fibrillation.Journal of the American Heart Association · 2025Article
- Cardiovascular-Kidney-Metabolic Health: Definition, Staging, Risk Assessment, and Therapeutic Considerations.Cardiology clinics · 2025Review
- Association of albuminuria with incident atrial fibrillation in healthy older adults.Clinical kidney journal · 2025Article
- Proteinuria Is Associated With an Increased Risk of Sudden Cardiac Arrest in the Young Population.Journal of the American Heart Association · 2025Article
- Proteinuria and the risk of Incident atrial fibrillation according to glycemic stages: a nationwide population-based cohort study.Cardiovascular diabetology · 2025Article
- Deletion of Sigmar1 leads to increased arterial stiffness and altered mitochondrial respiration resulting in vascular dysfunction.Frontiers in physiology · 2024Article
- Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels.Frontiers in physiology · 2023Article
- Bidirectional Association Between Kidney Function and Atrial Fibrillation: A Population-Based Cohort Study.Journal of the American Heart Association · 2022Article
- Association of proteinuria and incident atrial fibrillation in patients with diabetes mellitus: a population-based senior cohort study.Scientific reports · 2021Article
- Association of proteinuria with incident atrial fibrillation in the general Japanese population.Journal of cardiology · 2021Article
- The Characteristics and Clinical Outcomes of Direct Oral Anticoagulantsin Patients with Atrial Fibrillation and Chronic Kidney Disease: From the Database of A Single-Center Registry.Journal of atrial fibrillation · 2020Article
- Newly detected atrial fibrillation is associated with cortex-involved ischemic stroke.Chinese medical journal · 2019Article
- CJournal of the American Heart Association · 2019Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly evidence suggests proteinuria is independently associated with incident atrial fibrillation (AF). We sought to investigate whether the association of proteinuria with incident AF is altered by kidney function. METHODS AND
resultsRetrospective cohort study using administrative healthcare databases in Ontario, Canada (2002-2015). A total of 736 666 patients aged ≥40 years not receiving dialysis and with no previous history of AF were included. Proteinuria was defined using the urine albumin-to-creatinine ratio (ACR) and kidney function by the estimated glomerular filtration rate (eGFR). The primary outcome was time to AF. Cox proportional models were used to determine the hazard ratio for AF censored for death, dialysis, kidney transplant, or end of follow-up. Fine and Grey models were used to determine the subdistribution hazard ratio for AF, with death as a competing event. Median follow-up was 6 years and 44 809 patients developed AF. In adjusted models, ACR and eGFR were associated with AF (
conclusionsProteinuria increases the risk of incident AF markedly in patients with intact kidney function compared with those with decreased kidney function. Screening and preventative strategies should consider proteinuria as an independent risk factor for AF.
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Registered trials
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