ArticleMolecular & cellular proteomics : MCP2017
Metaproteomics reveals functional differences in intestinal microbiota development of preterm infants.
Article in Molecular & cellular proteomics : MCP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- A systematic review of the factors influencing microbial colonization of the preterm infant gut.Gut microbesPooled it
- Synbiotic supplementation leads to gut microbiome communities with functional capacity linked to better brain white matter development in preterm infants.Gut microbes · 2026Trial
- Variation in the early-life interdigital skin microbiota of lambs in a commercial sheep flock.Frontiers in veterinary science · 2026Article
- Gut Microbiota and Neurodevelopment in Preterm Infants: Mechanistic Insights and Prospects for Clinical Translation.Microorganisms · 2025Review
- Gut virome: New key players in the pathogenesis of inflammatory bowel disease.World journal of methodology · 2025Review
- Changes in the intestinal microbiome of the preterm baby associated with stopping non-invasive pressure support: a prospective cohort study.BMJ paediatrics open · 2024Article
- Gut microbiota in preterm infants with late-onset sepsis and pneumonia: a pilot case-control study.BMC microbiology · 2024Article
- The Association of Neonatal Gut Microbiota Community State Types with Birth Weight.Children (Basel, Switzerland) · 2024Article
- The Importance of a Healthy Microbiome in Pregnancy and Infancy and Microbiota Treatment to Reverse Dysbiosis for Improved Health.Antibiotics (Basel, Switzerland) · 2023Review
- Assessment of infant outgrowth of cow's milk allergy in relation to the faecal microbiome and metaproteome.Scientific reports · 2023Article
- Necrotizing Enterocolitis: The Role of Hypoxia, Gut Microbiome, and Microbial Metabolites.International journal of molecular sciences · 2023Review
- Development of the gut microbiome in early life.Experimental physiology · 2022Review
- Antibiotic Exposure, Common Morbidities and Main Intestinal Microbial Groups in Very Preterm Neonates: A Pilot Study.Antibiotics (Basel, Switzerland) · 2022Article
- Inferring early-life host and microbiome functions by mass spectrometry-based metaproteomics and metabolomics.Computational and structural biotechnology journal · 2022Review
- First encounters of the microbial kind: perinatal factors direct infant gut microbiome establishment.Microbiome research reports · 2022Review
- The first fungi: mode of delivery determines early life fungal colonization in the intestine of preterm infants.Microbiome research reports · 2022Article
- Aberrant gut-microbiota-immune-brain axis development in premature neonates with brain damage.Cell host & microbe · 2021Article
- Article
- Deep learning for peptide identification from metaproteomics datasets.Journal of proteomics · 2021Article
- Maturation of the preterm gastrointestinal tract can be defined by host and microbial markers for digestion and barrier defense.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDevelopment of the gastrointestinal tract and immune system can be modulated by the gut microbiota. Establishment of the intestinal microbiota, in its turn, is affected by host and environmental factors. As such, development of the gut microbiota is greatly impacted in preterm infants, who have an immature gut and are exposed to factors like hospitalization, caesarean section, antibiotics, and respiratory support.
designWe analyzed fecal microbiota composition and activity of ten preterm infants (gestational age 25-30 weeks; birthweight 630-1750 g) during the first six postnatal weeks through metaproteomics (LC-MS/MS) and 16S-rRNA gene sequencing.
resultsA gestational-age-dependent microbial signature is observed, enabling microbiota-based differentiation between extremely preterm (25-27 weeks gestation) and very preterm (30 weeks gestation) infants. In very preterm infants, the intestinal microbiota developed toward a
conclusionWe speculate that gestational age and its associated intensity of care (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.