Evidence map›Paper›PMID 28684537›Full record

Trial reportBlood2017

Pomalidomide, bortezomib, and dexamethasone for patients with relapsed lenalidomide-refractory multiple myeloma.

Jonas Paludo, Joseph R Mikhael, Betsy R LaPlant, Alese E Halvorson, Shaji Kumar, Morie A Gertz, Suzanne R Hayman, Francis K Buadi, Angela Dispenzieri, John A Lust and 18 more

Open access · bronzeAbstract readClinical Trial, Phase IClinical Trial, Phase IIMulticenter Study
In one paragraph

Trial report in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
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  13. The Ubiquitin System: An Emerging Therapeutic Target for Lung Cancer.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 4 institutions in 1 country.

Jonas PaludoDivision of Hematology, Mayo Clinic, Rochester, MN.ORCID 0000-0002-7350-5531
Joseph R MikhaelMayo Clinic Arizona, Scottsdale, AZ.
Betsy R LaPlantDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
Alese E HalvorsonDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
Shaji KumarDivision of Hematology, Mayo Clinic, Rochester, MN.
Morie A GertzDivision of Hematology, Mayo Clinic, Rochester, MN.
Suzanne R HaymanDivision of Hematology, Mayo Clinic, Rochester, MN.
Francis K BuadiDivision of Hematology, Mayo Clinic, Rochester, MN.
Angela DispenzieriDivision of Hematology, Mayo Clinic, Rochester, MN.
John A LustDivision of Hematology, Mayo Clinic, Rochester, MN.
Prashant KapoorDivision of Hematology, Mayo Clinic, Rochester, MN.
Nelson LeungDivision of Hematology, Mayo Clinic, Rochester, MN.
Stephen J RussellDivision of Hematology, Mayo Clinic, Rochester, MN.
David DingliDivision of Hematology, Mayo Clinic, Rochester, MN.
Ronald S GoDivision of Hematology, Mayo Clinic, Rochester, MN.
Yi LinDivision of Hematology, Mayo Clinic, Rochester, MN.
Wilson I GonsalvesDivision of Hematology, Mayo Clinic, Rochester, MN.
Rafael FonsecaMayo Clinic Arizona, Scottsdale, AZ.
P Leif BergsagelMayo Clinic Arizona, Scottsdale, AZ.
Vivek RoyMayo Clinic Florida, Jacksonville, FL; and.
Taimur SherMayo Clinic Florida, Jacksonville, FL; and.
Asher A Chanan-KhanMayo Clinic Florida, Jacksonville, FL; and.
Sikander AilawadhiMayo Clinic Florida, Jacksonville, FL; and.
A Keith StewartMayo Clinic Arizona, Scottsdale, AZ.
Craig B ReederMayo Clinic Arizona, Scottsdale, AZ.
Paul G RichardsonDana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
S Vincent RajkumarDivision of Hematology, Mayo Clinic, Rochester, MN.
Martha Q LacyDivision of Hematology, Mayo Clinic, Rochester, MN.
Mayo Clinic in Arizona · USJacksonville College · USMayo Clinic · USHarvard University · US

Funding

Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple MyelomaP50CA186781 · NCI · MAYO CLINIC ARIZONA · PI Rafael Fonseca · 2015 to 2026
$25.5M
Mutations that Distinguish Benign from Malignant Plasma Cell NeoplasamsR01CA195688 · NCI · MAYO CLINIC ARIZONA · PI BERGSAGEL, PETER LEIF · 2016 to 2020
$1.9M
NCI NIH HHS P50 CA186781NCI NIH HHS R01 CA195688
6 · The paper itself

Abstract

This phase 1/2 trial evaluated the maximum tolerated doses, safety, and efficacy of pomalidomide, bortezomib, and dexamethasone (PVD) combination in patients with relapsed lenalidomide-refractory multiple myeloma (MM). In phase 1, dose level 1 consisted of pomalidomide (4 mg by mouth on days 1 to 21), IV or subcutaneous bortezomib (1.0 mg/m

Indexed as

AgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsDexamethasoneDisease-Free SurvivalFemaleHumansLenalidomideMaleMaximum Tolerated DoseMiddle AgedMultiple MyelomaThalidomideTreatment OutcomeDexamethasoneLenalidomidepomalidomideThalidomide

Identifiers

PMID28684537
PMCPMC5606008
OpenAlexW2512928744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.