Evidence map›Paper›PMID 28684459›Full record

ReviewAmerican journal of physiology. Gastrointestinal and liver physiology2017

Dclk1-expressing tuft cells: critical modulators of the intestinal niche?

Moritz Middelhoff, C Benedikt Westphalen, Yoku Hayakawa, Kelley S Yan, Michael D Gershon, Timothy C Wang, Michael Quante

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Gastrointestinal and liver physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 93 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Influenza-induced tuft cell expansion alters ILC-mediated inflammation.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Protein Marker-Dependent Drug Discovery Targeting Breast Cancer Stem Cells.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. American journal of physiology. Gastrointestinal and liver physiology · 2023
    Article
  19. Article
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Moritz MiddelhoffDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, New York.
C Benedikt WestphalenMedizinische Klinik und Poliklinik III, Klinikum der Universität München, Munich, Germany.
Yoku HayakawaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kelley S YanDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, New York.
Michael D GershonDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
Timothy C WangDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, New York.
Michael QuanteII. Medizinische Klinik, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; michael.quante@tum.de.
Columbia University Irving Medical Center · USLMU Klinikum · DETechnical University of Munich · DEThe University of Tokyo · JP

Funding

Intestinal Stem Cell Consortium Coordinating CenterU01DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2009 to 2018
$6.5M
Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3M
Regulation of Active and Quiescent Intestinal Stem CellsK08DK096048 · NIDDK · STANFORD UNIVERSITY · PI YAN, KELLEY · 2012 to 2016
$717k
Enteroendocrine Cell Subsets with Reserve Stem Cell FunctionR03DK114656 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YAN, KELLEY · 2017 to 2018
$160k
NIDDK NIH HHS K08 DK096048NIDDK NIH HHS R03 DK114656NIDDK NIH HHS U01 DK085532NIDDK NIH HHS U24 DK085532
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCellular MicroenvironmentChemoreceptor CellsDoublecortin-Like KinasesHumansIntestinal MucosaIntracellular Signaling Peptides and ProteinsModels, BiologicalMultipotent Stem CellsProtein Serine-Threonine KinasesRegenerationStem Cell NicheDCLK1 protein, humanDoublecortin-Like KinasesIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine Kinasescancer initiationinflammationintestinal stem cellsniche celltuft cell

Identifiers

PMID28684459
PMCPMC5668570
OpenAlexW2728214347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.