Observational studyHeart (British Cardiac Society)2017
Impact of the left ventricular mass index on the outcomes of severe aortic stenosis.
Observational study in Heart (British Cardiac Society), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Discharge NT-proBNP predicts 2-year outcomes after TAVR but not after SAVR in preserved ejection fraction: a propensity-matched cohort study.Open heart · 2026Article
- Article
- Increased left ventricular remodelling index in paradoxical low-flow severe aortic stenosis with preserved left ventricular ejection fraction compared to normal-flow severe aortic stenosis.Singapore medical journal · 2026Article
- Increasing Left Ventricular Mass and Death in Men and Women Investigated With Echocardiography.Journal of the American Heart Association · 2025Article
- Prognostic value of longitudinal strain relative apical sparing in severe aortic stenosis patients undergoing TAVR.ESC heart failure · 2025Article
- Impact of Left Ventricular Mass on Mortality in Symptomatic Severe Aortic Stenosis: A Sex-Specific Analysis.Life (Basel, Switzerland) · 2025Article
- Associations between new-onset postoperative atrial fibrillation and changes in left ventricular mass index in patients undergoing transcatheter aortic valve replacement.BMC cardiovascular disorders · 2025Article
- CysC as a predictor of left ventricular remodeling and major adverse cardiovascular events in patients with acute myocardial infarction.Frontiers in cardiovascular medicine · 2025Article
- Female showed favorable left ventricle hypertrophy regression during post-TAVR follow-up.The Kaohsiung journal of medical sciences · 2024Article
- Optimal treatment of asymptomatic patients with severe aortic stenosis: protocol of a prospective, multicentre, registry study.BMJ open · 2023Article
- Article
- Left ventricular hypertrophy as a predictor of cardiovascular outcomes after transcatheter aortic valve replacement.ESC heart failure · 2023Observational
- Clinical, echocardiographic and prognostic outcomes of patients with concordant and discordant high-gradient aortic stenosis in an Asian cohort.The international journal of cardiovascular imaging · 2022Article
- Implication of Different ECG Left Ventricular Hypertrophy in Patients Undergoing Transcatheter Aortic Valve Replacement.Journal of the American Heart Association · 2022Observational
- Long term effects of surgical and transcatheter aortic valve replacement on FFRThe international journal of cardiovascular imaging · 2022Article
- Outcome of aortic stenosis according to invasive cardiac damage staging after transcatheter aortic valve replacement.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Article
- The Early Bird Catches the Worm: Should Severe LVH Be an Indication for Early TAVR?JACC. Cardiovascular interventions · 2020Article
- Sex and regional differences in myocardial plasticity in aortic stenosis are revealed by 3D model machine learning.European heart journal. Cardiovascular Imaging · 2020Article
- Cardiac Magnetic Resonance Feature Tracking in Aortic Stenosis: Exploration of Strain Parameters and Prognostic Value in Asymptomatic Patients with Preserved Ejection Fraction.Korean journal of radiology · 2020Article
- Determinants and prognostic implications of left ventricular mechanical dispersion in aortic stenosis.European heart journal. Cardiovascular Imaging · 2019Article
Corrections and comments
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Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo elucidate the factors associated with high left ventricular mass index (LVMI) and to test the hypothesis that high LVMI is associated with worse outcome in severe aortic stenosis (AS).
methodsWe analysed 3282 patients with LVMI data in a retrospective multicentre registry enrolling consecutive patients with severe AS in Japan. The management strategy, conservative or initial aortic valve replacement (AVR), was decided by the attending physician. High LVMI was defined as LVMI >115 g/m
resultsAge was mean 77 (SD 9.6) years and peak aortic jet velocity (Vmax) was 4.1 (0.9) m/s. The factors associated with high LVMI (n=2374) included female, body mass index ≥22, absence of dyslipidemia, left ventricular ejection fraction <50%, Vmax ≥4 m/s, regurgitant valvular disease, hypertension, anaemia and end-stage renal disease. In the conservative management cohort (normal LVMI: n=691, high LVMI: n=1480), the excess adjusted 5-year risk of high LVMI was significant (HR: 1.53, 95% CI 1.26 to 1.85, p<0.001). In the initial AVR cohort (normal LVMI: n=217, high LVMI: n=894), the risk did not differ significantly between the two groups (HR: 0.96, 95% CI 0.60 to 1.55, p=0.88). There was a significant interaction between the initial treatment strategy and the risk of high LVMI (p=0.016).
conclusionsThe deleterious impact of high LVMI on outcome was observed in patients managed conservatively, but not observed in patients managed with initial AVR. TRIAL REGISTRATION NUMBER: UMIN000012140; Post-results.
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