Evidence map›Paper›PMID 28684316›Full record

ArticleBiochemical and biophysical research communications2017

Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2.

Bogeon Yun, HeeJung Lee, Roger Powell, Nichole Reisdorph, Heather Ewing, Michael H Gelb, Ku-Lung Hsu, Benjamin F Cravatt, Christina C Leslie

Abstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. The Phospholipase AJournal of lipid and atherosclerosis · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Bogeon YunDepartment of Pediatrics, National Jewish Health, Denver, CO, 80206, USA.
HeeJung LeeDepartment of Pediatrics, National Jewish Health, Denver, CO, 80206, USA.
Roger PowellDepartment of Immunology, National Jewish Health, Denver, CO, 80206, USA.
Nichole ReisdorphDepartment of Immunology, National Jewish Health, Denver, CO, 80206, USA.
Heather EwingDepartment of Chemistry, University of Washington, Seattle, WA, 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
Michael H GelbDepartment of Chemistry, University of Washington, Seattle, WA, 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
Ku-Lung HsuDepartment of Chemistry, University of Virginia, Charlottesville, VA, 22904, USA.
Benjamin F CravattDepartment of Chemical Physiology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Christina C LeslieDepartment of Pediatrics, National Jewish Health, Denver, CO, 80206, USA. Electronic address: lesliec@njhealth.org.
National Jewish Health · USUniversity of Washington · USScripps Research Institute · USUniversity of Virginia · US

Funding

CHEMOPROTEOMIC METHODS FOR SERINE HYDROLASE INHIBITOR DEVELOPMENTR01DA033760 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI CRAVATT, BENJAMIN F, SCAMPAVIA, LOUIS DANIEL · 2012 to 2021
$5.1M
Identity of a serine hydrolase that controls mitochondrial calcium and cell deathR21ES025015 · NIEHS · NATIONAL JEWISH HEALTH · PI LESLIE, CHRISTINA CARROLL · 2015 to 2016
$436k
NIDA NIH HHS R01 DA033760NIEHS NIH HHS R21 ES025015
6 · The paper itself

Abstract

The serine hydrolase inhibitors pyrrophenone and KT195 inhibit cell death induced by A23187 and H

Indexed as

AnimalsApoptosisCalciumCell LineDose-Response Relationship, DrugEndoplasmic ReticulumGroup IV Phospholipases A2Hydrogen PeroxideHydrolasesMiceMice, KnockoutPhospholipase A2 InhibitorsPyrrolidinesStructure-Activity RelationshipAbhd2 protein, mouseCalciumGroup IV Phospholipases A2Hydrogen PeroxideHydrolasesPhospholipase A2 InhibitorsPyrrolidinespyrrophenoneABHD2CalciumCell deathEndoplasmic reticulumH(2)O(2)MitochondriaPyrrophenoneSerine hydrolase

Identifiers

PMID28684316
PMCPMC5658124
OpenAlexW2732186280

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.