Evidence map›Paper›PMID 28684207›Full record

ReviewTrends in immunology2017

Regulation of the Immune System by Laminins.

Thomas Simon, Jonathan S Bromberg

Open access · greenAbstract readReview
In one paragraph

Review in Trends in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Correlation ofCancers · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. NK cell activity in the tumor microenvironment.Frontiers in cell and developmental biology · 2025
    Review
  15. Article
  16. Article
  17. Vascular Extracellular Matrix in Atherosclerosis.International journal of molecular sciences · 2024
    Review
  18. Article
  19. The Binding ofInternational journal of molecular sciences · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Thomas SimonDepartments of Surgery and Microbiology and Immunology, Center for Vascular and Inflammatory Disease, University of Maryland School of Medicine, Baltimore, MD, USA.
Jonathan S BrombergDepartments of Surgery and Microbiology and Immunology, Center for Vascular and Inflammatory Disease, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: jbromberg@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Induction and Migration of Regulatory T Cells: Role of LymphotoxinR01AI062765 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BROMBERG, JONATHAN S · 2005 to 2019
$5.6M
Lymph Node Structure and Function in Tolerance: Role of LamininsR01AI114496 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BROMBERG, JONATHAN S · 2015 to 2024
$4.2M
Transplantation Tolerance: T Cell TraffickingR01AI041428 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROMBERG, JONATHAN S · 1997 to 2012
$3.3M
Regulatory T Cells and Lymphatic Endothelial Cells: Regulatory Interactions for Migration and SuppressionR37AI062765 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Jonathan S Bromberg · 2021 to 2026
$2.9M
Lymphoid Structure in ToleranceR01AI072039 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BROMBERG, JONATHAN S · 2007 to 2010
$1.6M
NIAID NIH HHS R01 AI041428NIAID NIH HHS R01 AI062765NIAID NIH HHS R01 AI072039NIAID NIH HHS R01 AI114496NIAID NIH HHS R37 AI062765
6 · The paper itself

Abstract

Laminins are trimeric proteins that are major components of the basement membranes that separate endothelia and epithelia from the underlying tissue. Sixteen laminin isoforms have been described, each with distinct tissue expression patterns and functions. While laminins have a critical structural role, recent evidence also indicates that they also impact the migration and functions of immune cells. Laminins are differentially expressed upon immunity or tolerance and orientate the immune response. This review will summarize the structure of laminins, the modulation of their expression, and their interactions with the immune system. Finally, the role of the laminins in autoimmune diseases and transplantation will be discussed.

Indexed as

Immune SystemAnimalsAutoimmune DiseasesBasement MembraneCell MovementEpithelial-Mesenchymal TransitionGene Expression RegulationHumansImmune ToleranceImmunityLamininLymphocytesProtein IsoformsTranscriptomeTransplantation ImmunologyLamininProtein Isoforms

Identifiers

PMID28684207
PMCPMC5669817
OpenAlexW2730731865

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.