Evidence map›Paper›PMID 28683982›Full record

ArticleThe International journal on drug policy2017

Research priorities to achieve universal access to hepatitis C prevention, management and direct-acting antiviral treatment among people who inject drugs.

Jason Grebely, Julie Bruneau, Jeffrey V Lazarus, Olav Dalgard, Philip Bruggmann, Carla Treloar, Matthew Hickman, Margaret Hellard, Teri Roberts, Levinia Crooks and 19 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in The International journal on drug policy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04610762 (Using the Cepheid GeneXpert HCV VL Fingerstick Test as a Diagnostic Tool for Chronic Hepatitis C Among Drug Users in Brussels), which is not on this map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04610762 completednot on this mapstarted 2020, after this paper: background citation

Using the Cepheid GeneXpert HCV VL Fingerstick Test as a Diagnostic Tool for Chronic Hepatitis C Among Drug Users in Brussels

TypeobservationalSponsorCentre Hospitalier Universitaire Saint PierreRan2020 to 2022Enrolled103ConditionsHepatitis C, ChronicArmsGeneXpert HCV VL Fingerstick test
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 63 citations in OpenAlex.

  1. Trial
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  11. Co-located Opioid Use Disorder and Hepatitis C Virus Treatment Is Not Only Right, But It Is Also the Smart Thing To Do as It Improves Outcomes!Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  12. [Antiviral treatment for hepatitis C among injecting drug users in the era of direct-acting antiviral agents].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020
    Review
  13. Article
  14. Hepatitis C Virus Reinfection Rate Among Persons Who Use Drugs and Are Maintained on Medication Treatment for Opioid Use Disorder.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 13 countries.

Jason GrebelyThe Kirby Institute, UNSW Sydney, Sydney, Australia. Electronic address: jgrebely@kirby.unsw.edu.au.
Julie BruneauCHUM Research Centre (CRCHUM), Centre Hospitalier de l'Université de Montréal, Montréal, Canada; Department of Family and Emergency Medicine, Faculty of Medicine, Université de Montréal, Montréal, Canada.
Jeffrey V LazarusCHIP, Rigshospitalet, University of Copenhagen, Denmark; Barcelona Institute of Global Health (ISGlobal), Hospital Clínic, Barcelona, Spain.
Olav DalgardDepartment of Infectious Diseases, Akershus University Hospital, Lørenskog, Norway; University of Oslo, Oslo, Norway.
Philip BruggmannArud Centres of Addiction Medicine, Zurich, Switzerland.
Carla TreloarCentre for Social Research in Health, UNSW Sydney, Sydney, Australia.
Matthew HickmanSchool of Social & Community Medicine, University of Bristol, Bristol, United Kingdom.
Margaret HellardDisease Elimination Program, Burnet Institute, Melbourne, Australia.
Teri RobertsMédecins sans Frontières, Geneva, Switzerland.
Levinia CrooksCentre for Social Research in Health, UNSW Sydney, Sydney, Australia; Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine, Sydney, Australia.
Håvard MidgardDepartment of Infectious Diseases, Akershus University Hospital, Lørenskog, Norway; Institute for Clinical Medicine, University of Oslo, Norway; Department of Gastroenterology, Oslo University Hospital, Norway.
Sarah LarneyNational Drug and Alcohol Research Centre, UNSW Australia, Sydney, Australia.
Louisa DegenhardtNational Drug and Alcohol Research Centre, UNSW Australia, Sydney, Australia.
Hannu AlhoUniversity of Helsinki, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland; Abdominal Center, Helsinki University Hospital, Helsinki, Finland.
Jude ByrneAustralian Injecting & Illicit Drug Users League, Canberra, Australia.
John F DillonNinewells Hospital and Medical School, Dundee, United Kingdom.
Jordan J FeldToronto Centre for Liver Disease, Sandra Rotman Centre for Global Health, University of Toronto, Toronto, Canada.
Graham FosterThe Liver Unit, Queen Mary University of London, London, United Kingdom.
David GoldbergSchool of Health and Life Sciences, Glasgow Caledonian University, Glasgow, United Kingdom; Health Protection Scotland, Glasgow, United Kingdom.
Andrew R LloydThe Kirby Institute, UNSW Sydney, Sydney, Australia.
Jens ReimerCentre for Interdisciplinary Addiction Research, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Geert RobaeysDepartment of Gastroenterology and Hepatology, Ziekenhuis Oost Limburg, Genk, Belgium; Department of Hepatology, UZ Leuven, Leuven, Belgium; Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.
Marta TorrensInstitute of Neuropsychiatry & Addictions-Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Universitat Autònoma de Barcelona, Barcelona, Spain.
Nat WrightSpectrum CIC, Wakefield, United Kingdom.
Icro MaremmaniSanta Chiara University Hospital, University of Pisa, Italy.
Brianna L NortonDivision of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States.
Alain H LitwinDivision of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States.
Gregory J DoreThe Kirby Institute, UNSW Sydney, Sydney, Australia.
International Network on Hepatitis in Substance Users
UNSW Sydney · AUAlbert Einstein College of Medicine · USOslo University Hospital · NOAddiction Switzerland · CHAlcohol and Drug Foundation · AUBurnet Institute · AUCentre Hospitalier de l’Université de Montréal · CAGlasgow Caledonian University · GBKiryu University · JPMédecins Sans Frontières · CHNinewells Hospital · GBQueen Mary University of London · GBSpectrum Community Health CIC · GBUniversitair Ziekenhuis Leuven · BEUniversitat Autònoma de Barcelona · ESUniversität Hamburg · DEUniversity of Bristol · GBUniversity of Copenhagen · DKUniversity of Helsinki · FIUniversity of Pisa · IT

Funding

Intensive Models of HCV Care for Injection Drug UsersR01DA034086 · NIDA · CLEMSON UNIVERSITY · PI LITWIN, ALAIN HARRIS · 2012 to 2016
$3.7M
Adaptation and testing of a primary care HCV group medical treatment interventionK23DA039060 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI NORTON, BRIANNA · 2015 to 2019
$948k
Department of Health RP-DG-0610-10055NIDA NIH HHS K23 DA039060NIDA NIH HHS R01 DA034086
6 · The paper itself

Abstract

Globally, it is estimated that 71.1 million people have chronic hepatitis C virus (HCV) infection, including an estimated 7.5 million people who have recently injected drugs (PWID). There is an additional large, but unquantified, burden among those PWID who have ceased injecting. The incidence of HCV infection among current PWID also remains high in many settings. Morbidity and mortality due to liver disease among PWID with HCV infection continues to increase, despite the advent of well-tolerated, simple interferon-free direct-acting antiviral (DAA) HCV regimens with cure rates >95%. As a result of this important clinical breakthrough, there is potential to reverse the rising burden of advanced liver disease with increased treatment and strive for HCV elimination among PWID. Unfortunately, there are many gaps in knowledge that represent barriers to effective prevention and management of HCV among PWID. The Kirby Institute, UNSW Sydney and the International Network on Hepatitis in Substance Users (INHSU) established an expert round table panel to assess current research gaps and establish future research priorities for the prevention and management of HCV among PWID. This round table consisted of a one-day workshop held on 6 September, 2016, in Oslo, Norway, prior to the International Symposium on Hepatitis in Substance Users (INHSU 2016). International experts in drug and alcohol, infectious diseases, and hepatology were brought together to discuss the available scientific evidence, gaps in research, and develop research priorities. Topics for discussion included the epidemiology of injecting drug use, HCV, and HIV among PWID, HCV prevention, HCV testing, linkage to HCV care and treatment, DAA treatment for HCV infection, and reinfection following successful treatment. This paper highlights the outcomes of the roundtable discussion focused on future research priorities for enhancing HCV prevention, testing, linkage to care and DAA treatment for PWID as we strive for global elimination of HCV infection.

Indexed as

Disease ManagementHealth Services AccessibilityResearchAntiviral AgentsHepatitis CHumansSubstance Abuse, IntravenousAntiviral AgentsDAADrug usersHCVIFN-freeInjectingPWID

Identifiers

PMID28683982
PMCPMC6049820
OpenAlexW2729748948

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.