ArticleParasites & vectors2017
Evaluation of immune protection induced by DNA vaccines from Haemaphysalis longicornis paramyosin in rabbits.
Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Growth and physiological regulations of discarded cocoa seed meal on mixed-bred rabbits in humid tropics.Tropical animal health and production · 2026Article
- Molecular characterization and immune efficacy of fructose-1,6-bisphosphate aldolase from Haemaphysalis longicornis (Acari: Ixodidae).Parasites & vectors · 2023Article
- Recent Advances in Tick Antigen Discovery and Anti-Tick Vaccine Development.International journal of molecular sciences · 2023Review
- Article
- Molecular Characterization and Expression Pattern of Paramyosin in Larvae and Adults of Yesso Scallop.Biology · 2022Article
- iTRAQ-based comparative proteomic analysis in different developmental stages of Echinococcus granulosus.Parasite (Paris, France) · 2021Article
- Cocktail Anti-Tick Vaccines: The Unforeseen Constraints and Approaches toward Enhanced Efficacies.Vaccines · 2020Review
- Ticks (Acari: Ixodoidea) in China: Geographical distribution, host diversity, and specificity.Archives of insect biochemistry and physiology · 2019Review
- Comparative proteomics of the vector Dermacentor reticulatus revealed differentially regulated proteins associated with pathogen transmission in response to laboratory infection with Rickettsia slovaca.Parasites & vectors · 2019Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHaemaphysalis longicornis is a blood-sucking ectoparasite that can cause diseases by transmitting some pathogens to humans and animals. Paramyosin (Pmy) is an immunomodulatory protein, which plays an important role in immune reactions against parasites. In this study, we evaluated the immune protection elicited by recombinant plasmids encoding H. longicornis Pmy in rabbits.
resultsRabbits vaccinated with pcDNA3.1(+)-Pmy developed high level of IgG compared to control group, suggesting that humoral immune response was induced by vaccination. On the fourth day after fed on the rabbit, some female adults died and the mortality rate from pcDNA3.1(+)-Pmy group (27.31%) was significantly higher than that of the control group (P < 0.0001). Other female ticks were attached to the rabbits until detachment, and the average engorgement weight, oviposition of female adult from pcDNA3.1(+)-Pmy group were 109.61 ± 4.24 mg and 48.39 ± 4.06 mg, respectively, which correspondingly resulted in 36 and 39% reduction compared with that of the control group (P < 0.0001). In brief, vaccination with Pmy plasmid DNA provided an overall efficacy of 50% in immune protection of rabbits.
conclusionsThis study suggested that Pmy DNA vaccine can induce effective humoral immune response and partially protected rabbit against H. longicornis infection.
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