Evidence map›Paper›PMID 28683805›Full record

ArticleBMC pulmonary medicine2017

Patient preferences for dry powder inhaler attributes in asthma and chronic obstructive pulmonary disease in France: a discrete choice experiment.

Natalia Hawken, Saku Torvinen, Mohamed-Elmoctar Neine, Ikbel Amri, Mondher Toumi, Samuel Aballéa, Adam Plich, Nicolas Roche

Open access · goldAbstract read
In one paragraph

Article in BMC pulmonary medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  5. Feedback systems in multi-dose dry powder inhalers.Postepy dermatologii i alergologii · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Natalia HawkenCreativ-Ceutical, Westblaak 92, 3012 KM, Rotterdam, The Netherlands. nataliahawken@yahoo.nl.
Saku TorvinenTeva Pharmaceuticals Europe BV, Amsterdam, The Netherlands.
Mohamed-Elmoctar NeineCreativ-Ceutical SARL, 215, rue du Faubourg St-Honoré, 75008, Paris, France.
Ikbel AmriCreativ-Ceutical, Rue du lac Huron Résidence Farah, Bloc B, 1053, Les Berges du Lac, Tunisia.
Mondher ToumiCreativ-Ceutical SARL, 215, rue du Faubourg St-Honoré, 75008, Paris, France.
Samuel AballéaCreativ-Ceutical SARL, 215, rue du Faubourg St-Honoré, 75008, Paris, France.
Adam PlichTeva Pharmaceuticals Europe BV, Amsterdam, The Netherlands.
Nicolas RocheRespiratory and Intensive Care Medicine, Cochin Hospital Group, AP-HP, University Paris Descartes, Paris, France.
Creativ-Ceutical (France) · FRTeva Pharmaceuticals (Netherlands) · NLHôpital Cochin · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDry powder inhalers (DPIs) are often used in asthma and chronic obstructive pulmonary disease (COPD) therapies. Using the discrete choice experiment (DCE) methodology, this study conducted in France was designed to assess patients' preferences for different attributes of DPIs.

methodsAttributes of DPIs were defined based on a literature review, patient focus group discussions and interviews with healthcare professionals (qualitative phase of the study). An online survey was then conducted among French patients with asthma or COPD to elicit patient preferences and willingness to pay (WTP) for these attributes using the DCE methodology (quantitative phase). A fractional factorial design including three blocks of 12 choice sets was created. Each choice set comprised three alternatives: two fictitious inhalers and the patient's current inhaler. Marginal utilities were estimated using a ranked ordered logit model. Interactions between attributes and disease (asthma or COPD) were tested.

resultsSix DPI attributes were defined based on the qualitative phase: ease of use/fool-proof priming; accurate and easy-to-read dose counter; dose confirmation; hygiene of the mouthpiece; flexibility of the device handling; ability to use the inhaler with breathing difficulties. Overall, 201 patients with asthma and 93 with COPD were included in the online survey. Patients with asthma placed most value on an inhaler that requires one step for dose preparation (WTP €4.83 [95% CI: €3.77-€5.90], relative to an inhaler requiring four steps) and one that could be used during episodes of breathing difficulties (WTP €4.49 [95% CI: €2.95-€6.02]). Patients with COPD placed most value on an inhaler that could be used during episodes of breathing difficulties (WTP €7.70 [95% CI: €5.65-€9.76]) and on the accuracy of the dose counter (WTP €5.87 [95% CI: €3.98-€ 7.77]).

conclusionThis study suggests that asthma and COPD patients would be willing to change their inhaler if they were offered the option of a new inhaler with improved characteristics and they place a high value on an inhaler with ease of use during breathing difficulty episodes.

Indexed as

Dry Powder InhalersPatient PreferenceAdultAgedAged, 80 and overAsthmaChoice BehaviorEquipment DesignFemaleFocus GroupsFranceHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveReview Literature as TopicAsthmaCOPDDiscrete choice experimentPatient preferenceWillingness to pay

Identifiers

PMID28683805
PMCPMC5501405
OpenAlexW2724360835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.