ArticleCell reports2017
Laminin Levels Regulate Tissue Migration and Anterior-Posterior Polarity during Egg Morphogenesis in Drosophila.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Initiation of rotational collective migration inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tissue geometry and mechanochemical feedback initiate rotational migration inbioRxiv : the preprint server for biology · 2025Article
- Basement membrane patterning by spatial deployment of a secretion-regulating protease.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Functional analysis of pathogenic variants in LAMB1-related leukoencephalopathy reveals genotype-phenotype correlations and suggests its role in glial cells.Human molecular genetics · 2025Article
- Extracellular matrix gene set and microRNA network in intestinal ischemia-reperfusion injury: Insights from RNA sequencing for diagnosis and therapy.World journal of gastrointestinal surgery · 2025Review
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- Finishing the egg.Genetics · 2024Article
- Basement membrane dynamics and mechanics in tissue morphogenesis.Biology open · 2023Review
- Constriction imposed by basement membrane regulates developmental cell migration.PLoS biology · 2023Article
- Specialized cells that sense tissue mechanics to regulate Drosophila morphogenesis.Developmental cell · 2023Article
- Integrins control epithelial stem cell proliferation in theFrontiers in cell and developmental biology · 2023Article
- Mechanobiology in oncology: basic concepts and clinical prospects.Frontiers in cell and developmental biology · 2023Review
- Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo.Development (Cambridge, England) · 2022Article
- βPS-Integrin acts downstream of Innexin 2 in modulating stretched cell morphogenesis in the Drosophila ovary.G3 (Bethesda, Md.) · 2021Article
- The careful control of Polo kinase by APC/C-Ube2C ensures the intercellular transport of germline centrosomes duringOpen biology · 2021Article
- To form and function: on the role of basement membrane mechanics in tissue development, homeostasis and disease.Open biology · 2021Review
- Gradient in cytoplasmic pressure in germline cells controls overlying epithelial cell morphogenesis.PLoS biology · 2020Article
- Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networks.PLoS genetics · 2020Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Basement membranes (BMs) are specialized extracellular matrices required for tissue organization and organ formation. We study the role of laminin and its integrin receptor in the regulation of tissue migration during Drosophila oogenesis. Egg production in Drosophila involves the collective migration of follicle cells (FCs) over the BM to shape the mature egg. We show that laminin content in the BM increases with time, whereas integrin amounts in FCs do not vary significantly. Manipulation of integrin and laminin levels reveals that a dynamic balance of integrin-laminin amounts determines the onset and speed of FC migration. Thus, the interplay of ligand-receptor levels regulates tissue migration in vivo. Laminin depletion also affects the ultrastructure and biophysical properties of the BM and results in anterior-posterior misorientation of developing follicles. Laminin emerges as a key player in the regulation of collective cell migration, tissue stiffness, and the organization of anterior-posterior polarity in Drosophila.
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