ArticleCell reports2017
Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Axo-axonic cells in neuropsychiatric disorders: a systematic review.Frontiers in cellular neuroscience · 2023Pooled it
- Cortical control of chandelier cells in neural codes.Frontiers in cellular neuroscience · 2022Pooled it
- Excitatory synapses onto axonic spines jump-start action potentials and route information flow.Nature neuroscience · 2026Article
- Axon initial segment structure and function in health and disease.Physiological reviews · 2025Review
- Theory of axo-axonic inhibition.PLoS computational biology · 2025Article
- Development of Prefrontal Circuits and Cognitive Abilities.Cold Spring Harbor perspectives in biology · 2024Review
- Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment structurally and functionally.Science advances · 2024Article
- Heterogeneous subpopulations of GABAiScience · 2024Article
- Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation.Neuron · 2024Article
- Bidirectional Regulation of GABALife (Basel, Switzerland) · 2024Review
- Reclusive chandeliers: Functional isolation of dentate axo-axonic cells after experimental status epilepticus.Progress in neurobiology · 2023Article
- RECLUSIVE CHANDELIERS: FUNCTIONAL ISOLATION OF DENTATE AXO-AXONIC CELLS AFTER EXPERIMENTAL STATUS EPILEPTICUS.bioRxiv : the preprint server for biology · 2023Article
- NKCC1 and KCC2 Chloride Transporters Have Different Membrane Dynamics on the Surface of Hippocampal Neurons.Cells · 2023Article
- Axon Initial Segment GABA Inhibits Action Potential Generation throughout Periadolescent Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics.eLife · 2023Article
- Chandelier cells shine a light on the formation of GABAergic synapses.Current opinion in neurobiology · 2023Review
- Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Development of network oscillations through adolescence in male and female rats.Frontiers in cellular neuroscience · 2023Article
- Step by step: cells with multiple functions in cortical circuit assembly.Nature reviews. Neuroscience · 2022Review
- Structure and function of axo-axonic inhibition.eLife · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Neuronal chloride levels are developmentally regulated. Early in life, high intracellular concentrations support chloride efflux and depolarization at GABAergic synapses. In mouse, intracellular chloride decreases over the first postnatal week in the somatodendritic compartment, eventually supporting mature, hyperpolarizing GABAergic inhibition. In contrast to this dendritic switch, it is less clear how GABAergic signaling at the axon initial segment (AIS) functions in mature pyramidal cells, as reports of both depolarization and hyperpolarization have been reported in the AIS past the first postnatal week. Here, we show that GABAergic signaling at the AIS of prefrontal pyramidal cells, indeed, switches polarity from depolarizing to hyperpolarizing but does so over a protracted periadolescent period. This is the most delayed maturation in chloride reversal in any structure studied to date and suggests that chandelier cells, which mediate axo-axonic inhibition, play a unique role in the periadolescent maturation of prefrontal circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.