Evidence map›Paper›PMID 28683266›Full record

ArticleNeuron2017

Disrupted Prefrontal Regulation of Striatal Subjective Value Signals in Psychopathy.

Jay G Hosking, Erik K Kastman, Hayley M Dorfman, Gregory R Samanez-Larkin, Arielle Baskin-Sommers, Kent A Kiehl, Joseph P Newman, Joshua W Buckholtz

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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  15. Psychopathy.Nature reviews. Disease primers · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jay G HoskingDepartment of Psychology, Harvard University, 52 Oxford St., Cambridge, MA 02138, USA. Electronic address: jhosking@fas.harvard.edu.
Erik K KastmanDepartment of Psychology, Harvard University, 52 Oxford St., Cambridge, MA 02138, USA.
Hayley M DorfmanDepartment of Psychology, Harvard University, 52 Oxford St., Cambridge, MA 02138, USA.
Gregory R Samanez-LarkinDepartment of Psychology and Neuroscience, Duke University, 417 Chapel Dr., Durham, NC 27708, USA.
Arielle Baskin-SommersDepartment of Psychology, Yale University, 2 Hillhouse Ave., New Haven, CT 06520, USA.
Kent A KiehlMIND Institute, 1101 Yale Blvd NE, Albuquerque, NM 87106, USA.
Joseph P NewmanDepartment of Psychology, University of Wisconsin-Madison, 1202 W Johnson St., Madison, WI 53706, USA.
Joshua W BuckholtzDepartment of Psychology, Harvard University, 52 Oxford St., Cambridge, MA 02138, USA; Center for Brain Science, Harvard University, 52 Oxford St., Cambridge, MA 02138, USA; Department of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02144, USA. Electronic address: joshua_buckholtz@harvard.edu.
Harvard University · USDuke University · USUniversity of Wisconsin–Madison · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Neuromodulation of Motivated Cognition and Decision Making Across AdulthoodR00AG042596 · NIA · YALE UNIVERSITY · PI SAMANEZ LARKIN, GREGORY R · 2014 to 2016
$730k
Neuromodulation of Motivated Cognition and Decision Making Across AdulthoodK99AG042596 · NIA · VANDERBILT UNIVERSITY · PI SAMANEZ LARKIN, GREGORY R · 2012 to 2012
$86k
NCATS NIH HHS UL1 TR001863NIA NIH HHS K99 AG042596NIA NIH HHS R00 AG042596
6 · The paper itself

Abstract

Psychopathy is a personality disorder with strong links to criminal behavior. While research on psychopathy has focused largely on socio-affective dysfunction, recent data suggest that aberrant decision making may also play an important role. Yet, the circuit-level mechanisms underlying maladaptive decision making in psychopathy remain unclear. Here, we used a multi-modality functional imaging approach to identify these mechanisms in a population of adult male incarcerated offenders. Psychopathy was associated with stronger subjective value-related activity within the nucleus accumbens (NAcc) during inter-temporal choice and with weaker intrinsic functional connectivity between NAcc and ventromedial prefrontal cortex (vmPFC). NAcc-vmPFC connectivity strength was negatively correlated with NAcc subjective value-related activity; however, this putative regulatory pattern was abolished as psychopathy severity increased. Finally, weaker cortico-striatal regulation predicted more frequent criminal convictions. These data suggest that cortico-striatal circuit dysregulation drives maladaptive decision making in psychopathy, supporting the notion that reward system dysfunction comprises an important neurobiological risk factor.

Indexed as

CriminalsPrisonersAdultAntisocial Personality DisorderDecision MakingFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysNucleus AccumbensPrefrontal CortexSeverity of Illness IndexVentral StriatumYoung Adultantisocialcortico-striataldelay discountingfunctional connectivitypsychopathyrewardself-controlstriatumvalue-based decision makingventromedial prefrontal cortex

Identifiers

PMID28683266
PMCPMC5796650
OpenAlexW2734173896

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.