Evidence map›Paper›PMID 28682948›Full record

ArticleAnesthesia and analgesia2017

Skeletal Muscle Metabolic Dysfunction in Patients With Malignant Hyperthermia Susceptibility.

Sara J Thompson, Sheila Riazi, Natalia Kraeva, Michael D Noseworthy, Tammy E Rayner, Jane E Schneiderman, Barbara Cifra, Greg D Wells

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anesthesia and analgesia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Unravelling the unseen metabolic changes in patients with malignant hyperthermia.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2021
    Article
  5. Sex-specific alterations in whole body energetics and voluntary activity in heterozygous R163C malignant hyperthermia-susceptible mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  6. Article
  7. Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sara J ThompsonFrom the *Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada; †Malignant Hyperthermia Investigation Unit, Toronto General Hospital, Toronto, Ontario, Canada; ‡Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada; §Department of Electrical and Computer Engineering, School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; ‖Department of Diagnostic Imaging, the Hospital for Sick Children, Toronto, Ontario, Canada; ¶Physiology and Experimental Medicine, the Hospital for Sick Children, Toronto, Ontario, Canada; and #Division of Cardiology, the Labatt Family Heart Centre, the Hospital for Sick Children, Toronto, Ontario, Canada.
Sheila Riazi
Natalia Kraeva
Michael D Noseworthy
Tammy E Rayner
Jane E Schneiderman
Barbara Cifra
Greg D Wells
University of Toronto · CAHospital for Sick Children · CA

Funding

The HH: A Large Cohort of Patients with Congenital Myopathies of Uncertain EtiologyR01AR071381 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI FILL, MICHAEL, RIAZI, SHEILA · 2017 to 2021
$2.7M
CIHRNIAMS NIH HHS R01 AR071381
6 · The paper itself

Abstract

backgroundMalignant hyperthermia (MH), a pharmacogenetic disorder of skeletal muscle, presents with a potentially lethal hypermetabolic reaction to certain anesthetics. However, some MH-susceptible patients experience muscle weakness, fatigue, and exercise intolerance in the absence of anesthetic triggers. The objective of this exploratory study was to elucidate the pathophysiology of exercise intolerance in patients tested positive for MH with the caffeine-halothane contracture test. To this end, we used phosphorus magnetic resonance spectroscopy, blood oxygen level-dependent functional magnetic resonance imaging (MRI), and traditional exercise testing to compare skeletal muscle metabolism in MH-positive patients and healthy controls.

methodsSkeletal muscle metabolism was assessed using phosphorus magnetic resonance spectroscopy and blood oxygen level-dependent functional MRI in 29 MH-positive patients and 20 healthy controls. Traditional measures of physical capacity were employed to measure aerobic capacity, anaerobic capacity, and muscle strength.

resultsDuring 30- and 60-second exercise, MH-positive patients had significantly lower ATP production via the oxidative pathway compared to healthy controls. MH-positive patients also had a longer recovery time with blood oxygen level-dependent functional MRI compared to healthy controls. Exercise testing revealed lower aerobic and anaerobic capacity in MH-positive patients compared to healthy controls.

conclusionsResults of this exploratory study suggest that MH-positive patients have impaired aerobic metabolism compared to healthy individuals. This could explain the exercise intolerance exhibited in MH-susceptible patient population.

Indexed as

AdultAnestheticsAnthropometryCaffeineCase-Control StudiesDisease SusceptibilityExercise TestFemaleHalothaneHumansMagnetic Resonance ImagingMaleMalignant HyperthermiaMetabolic DiseasesMiddle AgedMuscle ContractionAnestheticsCaffeineHalothaneOxygen

Identifiers

PMID28682948
PMCPMC9940015
OpenAlexW2729909209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.