Trial reportMedicine2017
Increased interhemispheric resting-state functional connectivity in healthy participants with insomnia symptoms: A randomized clinical consort study.
Trial report in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Structural Alterations in Large-scale Brain Networks and Their Relationship with Sleep Disturbances in the Adolescent Population.Scientific reports · 2020Trial
- Alterations in subgenual anterior cingulate cortex functional connectivity underlie depressive symptoms in chronic insomnia disorder.Frontiers in psychiatry · 2026Article
- Multimodal integration of homotopic connectivity and transcriptomic signatures in major depressive disorder with sleep disorder comorbidity.BMC psychiatry · 2025Article
- Altering Temporal Dynamics of Sleepiness and Mood During Sleep Deprivation: Evidence from Resting-State EEG Microstates.Brain sciences · 2025Article
- Insomnia and stress: the mediating roles of frontoparietal network.Brain imaging and behavior · 2024Article
- Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features.Psychoradiology · 2022Review
- Review
- Functional Connectivity Density in the Sensorimotor Area is Associated with Sleep Latency in Patients with Primary Insomnia.Neuropsychiatric disease and treatment · 2022Article
- Cerebral functional networks during sleep in young and older individuals.Scientific reports · 2021Article
- Neural basis underlying the trait of attachment anxiety and avoidance revealed by the amplitude of low-frequency fluctuations and resting-state functional connectivity.BMC neuroscience · 2021Article
- Brain reactivity using fMRI to insomnia stimuli in insomnia patients with discrepancy between subjective and objective sleep.Scientific reports · 2021Article
- Integrating sleep, neuroimaging, and computational approaches for precision psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- The homotopic connectivity of the functional brain: a meta-analytic approach.Scientific reports · 2019Article
- Multivariate Pattern Classification of Primary Insomnia Using Three Types of Functional Connectivity Features.Frontiers in neurology · 2019Article
- Article
- Altered Default Mode and Sensorimotor Network Connectivity With Striatal Subregions in Primary Insomnia: A Resting-State Multi-Band fMRI Study.Frontiers in neuroscience · 2018Article
- Abnormal Functional Connectivity of Anterior Cingulate Cortex in Patients With Primary Insomnia: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in aging neuroscience · 2018Article
- Aberrant Effective Connectivity of the Right Anterior Insula in Primary Insomnia.Frontiers in neurology · 2018Article
- Disrupted interhemispheric functional connectivity in chronic insomnia disorder: a resting-state fMRI study.Neuropsychiatric disease and treatment · 2018Article
- Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints.Frontiers in human neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbnormalities within the insular cortex of the salience and thalamus of the hyperarousal network have been increasingly reported in healthy participants with insomnia symptoms by recent resting-state functional magnetic resonance imaging (rsfMRI) studies. However, little is known about the changes in functional interaction between the bilateral cerebral hemispheres in healthy participants with insomnia symptoms.
methodsIn a randomized trial, 27 healthy participants with insomnia symptoms and 27 age-, gender-, and educational level-matched healthy participants without insomnia symptoms underwent rsfMRI. Voxel-mirrored homotopic connectivity (VMHC) was used to measure functional connectivity between any pair of symmetrical interhemispheric voxels (i.e., functional homotopy).
resultsThe healthy participants with insomnia symptoms displayed significantly increased VMHC compared to healthy participants without insomnia symptoms in the bilateral thalamus/posterior insula (including anterior insula), fusiform, middle cingulate gyrus, inferior parietal lobe, and postcentral gyrus. No regions of decreased VMHC were detected in healthy participants with insomnia symptoms. There were significantly positive correlations between the VMHC values in the anterior cingulate cortex (ACC) and sleep disturbance scores in all healthy participants.
conclusionsInsomnia is associated with substantial impairment of interhemispheric coordination within the default mode (ACC), salience (insula), hyperarousal (thalamus/posterior insula), and visual (fusiform) networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.