Evidence map›Paper›PMID 28682534›Full record

ArticleThe Journal of clinical psychiatry2017

Objectively Assessed Sleep Variability as an Acute Warning Sign of Suicidal Ideation in a Longitudinal Evaluation of Young Adults at High Suicide Risk.

Rebecca A Bernert, Melanie A Hom, Naomi G Iwata, Thomas E Joiner

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in The Journal of clinical psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03991650 (REMOTE), which is not on this map. Cited by 81 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 3 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03991650 completednot on this mapstarted 2019, after this paper: background citation

REMOTE: Monitoring Telemedicine Platform in Patients With Anxiety Symptoms and Alcohol Use Disorder: Smartphone and Wearable Sensors

Typeobservational_patient_registrySponsorhumanITcareRan2019 to 2019Enrolled44ConditionsAnxiety Disorders, Alcohol Use Disorder, Depressive DisorderArmsMonitoring with a device
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 3 syntheses or guidelines pooled it, 174 citations in OpenAlex.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rebecca A BernertSuicide Prevention Research Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94304-5797. rbernert@stanford.edu.
Melanie A HomDepartment of Psychology, Florida State University, Tallahassee, Florida, USA.
Naomi G IwataStanford Mood Disorders Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.
Thomas E JoinerDepartment of Psychology, Florida State University, Tallahassee, Florida, USA.
Florida State University · US

Funding

A Sleep-Oriented Intervention for Suicidal BehaviorsK23MH093490 · NIMH · STANFORD UNIVERSITY · PI BERNERT, REBECCA A · 2012 to 2016
$907k
Sleep Disturbances as a Suicide Risk FactorF31MH080470 · NIMH · FLORIDA STATE UNIVERSITY · PI BERNERT, REBECCA A · 2007 to 2008
$62k
NIMH NIH HHS F31 MH080470NIMH NIH HHS K23 MH093490
6 · The paper itself

Abstract

objectiveYoung adults attempt suicide at disproportionately high rates relative to other groups and demonstrate high rates of sleep disturbance. No study has yet prospectively evaluated disturbed sleep as an acute indicator of risk using an objective index of sleep. We investigated objective and subjective parameters of disturbed sleep as a warning sign of suicidal ideation among young adults over an acute period.

methodsA longitudinal study across a 21-day observation period and 3 time points. Fifty of 4,847 participants (aged 18-23 years) were prescreened from a university undergraduate research pool (February 2007-June 2008) on the basis of suicide attempt history and recent suicidal ideation. Actigraphic and subjective sleep parameters were evaluated as acute predictors of suicidal ideation (Beck Scale for Suicide Ideation), with adjustment for baseline symptoms. Hierarchical regression analyses were employed to predict residual change scores.

resultsNinety-six percent of participants (n = 48) endorsed a suicide attempt history. Mean actigraphy values revealed objectively disturbed sleep parameters; 78% (n = 39) and 36% (n = 18) endorsed clinically significant insomnia and nightmares, respectively. When results were controlled for baseline suicidal and depressive symptoms, actigraphic and subjective sleep parameters predicted suicidal ideation residual change scores at 7- and 21-day follow-ups (P < .001). Specifically, actigraphy-defined variability in sleep timing, insomnia, and nightmares predicted increases in suicidal ideation (P < .05). In a test of competing risk factors, sleep variability outperformed depressive symptoms in the longitudinal prediction of suicidal ideation across time points (P < .05).

conclusionsObjectively and subjectively measured sleep disturbances predicted acute suicidal ideation increases in this population, independent of depressed mood. Self-reported insomnia and nightmares and actigraphically assessed sleep variability emerged as acute warning signs of suicidal ideation. These findings highlight the potential utility of sleep as a proposed biomarker of suicide risk and a therapeutic target.

Indexed as

Suicidal IdeationActigraphyAdolescentAdultBiomarkersDepressionDreamsFemaleHumansLongitudinal StudiesMalePrognosisRisk AssessmentSleep Initiation and Maintenance DisordersSleep Wake DisordersYoung AdultBiomarkers

Identifiers

PMID28682534
PMCPMC6613567
OpenAlexW2725649988

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.