Evidence map›Paper›PMID 28682469›Full record

ReviewMedicinal research reviews2018

A

Kenneth A Jacobson, Stefania Merighi, Katia Varani, Pier Andrea Borea, Stefania Baraldi, Mojgan Aghazadeh Tabrizi, Romeo Romagnoli, Pier Giovanni Baraldi, Antonella Ciancetta, Dilip K Tosh and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in Medicinal research reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. 4'-Thionucleosides as adenosine AMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Macrophage Plg-RJournal of thrombosis and haemostasis : JTH · 2026
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Synthesis of Adenine Nucleosides with a Reactive (Molecules (Basel, Switzerland) · 2025
    Article
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892.ORCID 0000-0001-8104-1493
Stefania MerighiDepartment of Medical Sciences, Pharmacology Section, University of Ferrara, Via Fossato di Mortara 17/19, 44121, Ferrara, Italy.
Katia VaraniDepartment of Medical Sciences, Pharmacology Section, University of Ferrara, Via Fossato di Mortara 17/19, 44121, Ferrara, Italy.
Pier Andrea BoreaDepartment of Medical Sciences, Pharmacology Section, University of Ferrara, Via Fossato di Mortara 17/19, 44121, Ferrara, Italy.
Stefania BaraldiDepartment of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17, 44121, Ferrara, Italy.
Mojgan Aghazadeh TabriziDepartment of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17, 44121, Ferrara, Italy.
Romeo RomagnoliDepartment of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17, 44121, Ferrara, Italy.
Pier Giovanni BaraldiDepartment of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17, 44121, Ferrara, Italy.
Antonella CiancettaMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892.
Dilip K ToshMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892.
Zhan-Guo GaoMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892.
Stefania GessiDepartment of Medical Sciences, Pharmacology Section, University of Ferrara, Via Fossato di Mortara 17/19, 44121, Ferrara, Italy.ORCID 0000-0002-2197-5611
University of Ferrara · ITNational Institutes of Health · US

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Intramural NIH HHS ZIA DK031117NULL ZIA DK031117-29
6 · The paper itself

Abstract

The A

Indexed as

Adenosine A3 Receptor AgonistsAllosteric SiteAnimalsArthritis, RheumatoidCarcinoma, HepatocellularClinical Trials as TopicCrystallography, X-RayHumansImmune SystemInflammationLiver NeoplasmsMiceMolecular Dynamics SimulationPsoriasisRatsReceptor, Adenosine A3Adenosine A3 Receptor AgonistsReceptor, Adenosine A3A3 adenosine receptorcancerdrug developmentinflammationtherapy

Identifiers

PMID28682469
PMCPMC5756520
OpenAlexW2727679898

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.