Evidence map›Paper›PMID 28682319›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2017

Neonatal abstinence syndrome and early childhood morbidity and mortality in Washington state: a retrospective cohort study.

C E Witt, K E Rudd, P Bhatraju, F P Rivara, S E Hawes, N S Weiss

Abstract read
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Prenatal Opioid Exposure and Neonatal Opioid Withdrawal Syndrome.Advances in experimental medicine and biology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Pediatric Primary Care Diagnoses Among Children with Intrauterine Opioid Exposure.Journal of health care for the poor and underserved · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Adverse neonatal outcomes associated with maternal severe mental health diagnoses and opioid use.Journal of perinatology : official journal of the California Perinatal Association · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

C E WittDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
K E RuddDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
P BhatrajuDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
F P RivaraDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
S E HawesDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
N S WeissDepartment of Epidemiology, University of Washington, Seattle, WA, USA.

Funding

RESPIRATORY RESEARCH TRAINING PROGRAMT32HL007287 · NHLBI · UNIVERSITY OF WASHINGTON · PI Kristina Anne Crothers, David J. Horne · 1985 to 2026
$16.7M
Pediatric Injury Research Training ProgramT32HD057822 · NICHD · UNIVERSITY OF WASHINGTON · PI CAROLYN A MC CARTY, Ali Rowhani-Rahbar · 2010 to 2026
$4.0M
NHLBI NIH HHS T32 HL007287NICHD NIH HHS T32 HD057822
6 · The paper itself

Abstract

objectiveThe objective of the study was to evaluate the association between neonatal abstinence syndrome (NAS) and long-term childhood morbidity and infant mortality. STUDY

designWe conducted a cohort study of infants born in Washington State during 1990 to 2008 who were diagnosed with NAS (n=1900) or were unexposed (n=12,283, frequency matched by birth year). 5-year hospital readmissions and infant mortality were ascertained.

resultsChildren with history of NAS had increased risk of readmission during the first 5 years of life relative to unexposed children; this remained statistically significant after adjustment for maternal age, maternal education, gestational age and intrapartum smoking status (readmission rates: NAS=21.3%, unexposed=12.7%, adjusted relative risk (aRR) 1.54, 95% confidence interval (CI) 1.37 to 1.73). NAS was associated with increased unadjusted infant mortality risk, but this did not persist after adjustment (aRR 1.94, 95% CI 0.99 to 3.80).

conclusionThe observed increased risk for childhood hospital readmission following NAS diagnosis argues for development of early childhood interventions to prevent morbidity.Journal of Perinatology advance online publication,.

Indexed as

AdultCase-Control StudiesChild, PreschoolComorbidityFemaleHumansInfantInfant, NewbornMaleNeonatal Abstinence SyndromeOpioid-Related DisordersPatient ReadmissionPregnancyPregnancy ComplicationsPrevalenceRetrospective Studies

Identifiers

PMID28682319
PMCPMC5630496

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.