ArticleeLife2017
Topological analysis of multicellular complexity in the plant hypocotyl.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Quantification of cell-type-specific plasmodesmata distribution in Arabidopsis roots reveals spatial and patterning dynamics.The Plant journal : for cell and molecular biology · 2026Article
- Topological analysis of 3D digital ovules identifies cellular patterns associated with ovule shape diversity.Development (Cambridge, England) · 2024Article
- Large-volume fully automated cell reconstruction generates a cell atlas of plant tissues.The Plant cell · 2024Article
- The D-Mercator method for the multidimensional hyperbolic embedding of real networks.Nature communications · 2023Article
- Tissues as networks of cells: towards generative rules of complex organ development.Journal of the Royal Society, Interface · 2023Review
- Composition, structure and robustness of Lichen guilds.Scientific reports · 2023Article
- Using positional information to provide context for biological image analysis with MorphoGraphX 2.0.eLife · 2022Article
- The Random Plots Graph Generation Model for Studying Systems with Unknown Connection Structures.Entropy (Basel, Switzerland) · 2022Article
- Plant multiscale networks: charting plant connectivity by multi-level analysis and imaging techniques.Science China. Life sciences · 2021Review
- An Extended Correlation Dimension of Complex Networks.Entropy (Basel, Switzerland) · 2021Article
- A Sight on Single-Cell Transcriptomics in Plants Through the Prism of Cell-Based Computational Modeling Approaches: Benefits and Challenges for Data Analysis.Frontiers in genetics · 2021Review
- Isolation of Lineage Specific Nuclei Based on Distinct Endoreduplication Levels and Tissue-Specific Markers to Study Chromatin Accessibility Landscapes.Plants (Basel, Switzerland) · 2020Article
- Efficient vasculature investment in tissues can be determined without global information.Journal of the Royal Society, Interface · 2020Article
- Plant behaviour in response to the environment: information processing in the solid state.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Global Topological Order Emerges through Local Mechanical Control of Cell Divisions in the Arabidopsis Shoot Apical Meristem.Cell systems · 2019Article
- 3DCellAtlas Meristem: a tool for the global cellular annotation of shoot apical meristems.Plant methods · 2019Article
- Fluorescein Transport Assay to Assess Bulk Flow of Molecules Through the Hypocotyl inBio-protocol · 2018Article
- Seedling Establishment: A Dimmer Switch-Regulated Process between Dark and Light Signaling.Plant physiology · 2018Review
- Network-based approaches to quantify multicellular development.Journal of the Royal Society, Interface · 2017Review
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Multicellularity arose as a result of adaptive advantages conferred to complex cellular assemblies. The arrangement of cells within organs endows higher-order functionality through a structure-function relationship, though the organizational properties of these multicellular configurations remain poorly understood. We investigated the topological properties of complex organ architecture by digitally capturing global cellular interactions in the plant embryonic stem (hypocotyl), and analyzing these using quantitative network analysis. This revealed the presence of coherent conduits of reduced path length across epidermal atrichoblast cell files. The preferential movement of small molecules along this cell type was demonstrated using fluorescence transport assays. Both robustness and plasticity in this higher order property of atrichoblast patterning was observed across diverse genetic backgrounds, and the analysis of genetic patterning mutants identified the contribution of gene activity towards their construction. This topological analysis of multicellular structural organization reveals higher order functions for patterning and principles of complex organ construction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.