Evidence map›Paper›PMID 28682183›Full record

ArticleJournal of the American College of Nutrition2017

Interaction between Nonsteroidal Anti-inflammatory Drugs and Low-fat Dietary Intervention on Colorectal Cancer Incidence; the Women's Health Initiative (WHI) Dietary Modification Trial.

Ikuko Kato, Dorothy Lane, Catherine R Womack, Cathryn H Bock, Lifang Hou, Jennifer H Lin, Chunyuan Wu, Jennifer Beebe Dimmer, Michael S Simon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American College of Nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Pharmacological plasticity-How do you hit a moving target?Pharmacology research & perspectives · 2019
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Ikuko Katoa Department of Oncology , Karmanos Cancer Institute at Wayne State University School of Medicine , Detroit , Michigan , USA.
Dorothy Lanec Department of Family , Population and Preventive Medicine, Stony Brook University , Stony Brook , New York , USA.
Catherine R Womackd Department of Medicine and Preventive Medicine , the University of Tennessee Health Science Center , Memphis , Tennessee , USA.
Cathryn H Bocka Department of Oncology , Karmanos Cancer Institute at Wayne State University School of Medicine , Detroit , Michigan , USA.
Lifang Houe Department of Preventive Medicine and the Robert H. Lurie Comprehensive Cancer Center Feinberg School of Medicine , Northwestern University , Evanston , Illinois , USA.
Jennifer H Linf Janssen Pharmaceutical Inc , Titusville , New Jersey , USA.
Chunyuan Wug Fred Hutchinson Cancer Research Center , Division of Public Health Sciences , Seattle , Washington , USA.
Jennifer Beebe Dimmera Department of Oncology , Karmanos Cancer Institute at Wayne State University School of Medicine , Detroit , Michigan , USA.
Michael S Simona Department of Oncology , Karmanos Cancer Institute at Wayne State University School of Medicine , Detroit , Michigan , USA.
Wayne State University · USFred Hutch Cancer Center · USJanssen (United States) · USRobert H. Lurie Comprehensive Cancer Center of Northwestern UniversityStony Brook University · USThe Barbara Ann Karmanos Cancer Institute · USUniversity of Tennessee Health Science Center · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042119 · WH · YESHIVA UNIVERSITY · PI WASSERTHEIL-SMOLLER, SYLVIA · 1994 to 2001
$2.2M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032101 · WH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GRIMM, RICHARD H · 1993 to 2000
$1.7M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032111 · WH · EMORY UNIVERSITY · PI WATTS, NELSON · 1993 to 2001
$1.6M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042123 · WH · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042109 · WH · STANFORD UNIVERSITY · PI STEFANICK, MARCIA L · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042114 · WH · KAISER FOUNDATION RESEARCH INSTITUTE · PI RITENBAUGH, CHERYL K · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042108 · WH · GEORGE WASHINGTON UNIVERSITY · PI HSIA, JUDITH · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042124 · WH · RUSH UNIVERSITY MEDICAL CENTER · PI BLACK, HENRY R · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042131 · WH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI O'SULLIVAN, MARY J · 1994 to 2000
$1.3M
WOMENS HEALTH INITIATIVE-N01WH22110N01WH022110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ROSS, PRENTICE · 1992 to 2006
$1.2M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032105 · WH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OBERMAN, ALBERT · 1993 to 2000
$1.2M
NCI NIH HHS P30 CA022453WHI NIH HHS N01 WH022110WHI NIH HHS N01 WH024152WHI NIH HHS N01 WH032100WHI NIH HHS N01 WH032101WHI NIH HHS N01 WH032102WHI NIH HHS N01 WH032105WHI NIH HHS N01 WH032106WHI NIH HHS N01 WH032108WHI NIH HHS N01 WH032109WHI NIH HHS N01 WH032111WHI NIH HHS N01 WH032112WHI NIH HHS N01 WH032113WHI NIH HHS N01 WH032115WHI NIH HHS N01 WH032118WHI NIH HHS N01 WH032119WHI NIH HHS N01 WH032122WHI NIH HHS N01 WH042107WHI NIH HHS N01 WH042108WHI NIH HHS N01 WH042109WHI NIH HHS N01 WH042110WHI NIH HHS N01 WH042111WHI NIH HHS N01 WH042112WHI NIH HHS N01 WH042113WHI NIH HHS N01 WH042114WHI NIH HHS N01 WH042115WHI NIH HHS N01 WH042116WHI NIH HHS N01 WH042117WHI NIH HHS N01 WH042118WHI NIH HHS N01 WH042119WHI NIH HHS N01 WH042120WHI NIH HHS N01 WH042121WHI NIH HHS N01 WH042122WHI NIH HHS N01 WH042123WHI NIH HHS N01 WH042124WHI NIH HHS N01 WH042125WHI NIH HHS N01 WH042126WHI NIH HHS N01 WH042129WHI NIH HHS N01 WH042130WHI NIH HHS N01 WH042131WHI NIH HHS N01 WH042132WHI NIH HHS N01 WH044221
6 · The paper itself

Abstract

backgroundThe Women's Health Initiative (WHI) Dietary Modification (DM) trial did not show that reductions in dietary fat accompanied by increases in vegetable and fruit consumption decrease the incidence of colorectal cancer. Secondary analyses suggested that aspirin use may modify the intervention effects of DM on colorectal cancer development, although a recent reanalysis including the postintervention period confirmed no main effect of the intervention on reducing colorectal cancer incidence Methods: We analyzed data from 48,834 postmenopausal women who were randomized into the low-fat DM (N = 19,540) or comparison (N = 29,294) group for an average 8.1 years and followed for an additional 9.4 years through August 31, 2014. Exposure to specific class(es) or strength(s) of nonsteroidal anti-inflammatory drugs (NSAIDs) was modeled at baseline and as time-dependent use through the 9-year clinic visit. A Cox proportional hazard model was employed to assess the association of the DM, medication use, and their interaction with colorectal cancer events.

resultsA total of 906 incident cases of colorectal cancer were identified during the intervention and postintervention periods. By both exposure models, we found that colorectal cancer incidence was not different in the DM from the comparison group among any type of NSAID users. None of the interactions with any category of NSAID use was statistically significant; however there was most modest evidence for an interaction (p = 0.07) with aspirin use at baseline (hazard ratio [HR] = 0.81, 95% confidence interval [CI], 0.60-1.11 for users; HR = 1.12, 95% CI, 0.97-1.30 for nonusers). Strength and duration of aspirin use at baseline did not alter the associations.

conclusionExtended follow-up of women in the WHI DM trial did not confirm combined protective effects of aspirin and low-fat diet on colorectal cancer risk among the postmenopausal women.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalAgedColorectal NeoplasmsDietary FatsFemaleHumansMiddle AgedProportional Hazards ModelsRisk FactorsAnti-Inflammatory Agents, Non-SteroidalDietary Fatsaspirinclinical trialcolorectal cancerLow-fat dietnonsteroidal anti-inflammatory drugs

Identifiers

PMID28682183
PMCPMC6094937
OpenAlexW2731531294

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.