ArticleAddiction biology2018
Cocaine and HIV are independently associated with neural activation in response to gain and loss valuation during economic risky choice.
Article in Addiction biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- A History of Methamphetamine Use Disorder in People with HIV Is Associated with Altered Functional Response to Risky Choice.Viruses · 2026Article
- From Neuroadaptation to Neuroprogression: Rethinking Chronic Cocaine Exposure Through a Model of Cocaine-Related Cerebropathy.Journal of clinical medicine · 2026Article
- Neural oscillations serving abstract reasoning are differentially associated with inflammatory markers in people with HIV.Brain, behavior, and immunity · 2026Article
- Diffusion connectometry reveals white matter substrates of individual differences in loss aversion.Scientific reports · 2025Article
- Methamphetamine related cues impact impulsive choice by decreasing loss aversion.BMC psychiatry · 2025Article
- Clustering of behavioral economic biases in decision-making and risk for cigarette smoking and other substance use in women and men.Preventive medicine · 2024Article
- Exploring the Loss Aversion Scale's psychometric properties in Spain.Scientific reports · 2024Article
- Loss aversion predicts cigarette smoking status across levels of sociodemographic characteristics.Experimental and clinical psychopharmacology · 2024Article
- Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review.Brain sciences · 2023Review
- Loss Aversion and Current, Former, and Never-Smoking Status.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Article
- Article
- Decision Making in Addictive Behaviors Based on Prospect Theory: A Systematic Review.Healthcare (Basel, Switzerland) · 2022Review
- HIV Tat and cocaine interactively alter genome-wide DNA methylation and gene expression and exacerbate learning and memory impairments.Cell reports · 2022Article
- Loss aversion and risk for cigarette smoking and other substance use.Drug and alcohol dependence · 2022Article
- Effects of substance use on monetary delay discounting among people who use stimulants with and without HIV: An ecological momentary assessment study.Experimental and clinical psychopharmacology · 2022Article
- Brain multimodal co-alterations related to delay discounting: a multimodal MRI fusion analysis in persons with and without cocaine use disorder.BMC neuroscience · 2021Article
- Hypoactivation in the precuneus and posterior cingulate cortex during ambiguous decision making in individuals with HIV.Journal of neurovirology · 2021Article
- Machine learning prediction of neurocognitive impairment among people with HIV using clinical and multimodal magnetic resonance imaging data.Journal of neurovirology · 2021Article
- Neural sensitivity to risk in adults with co-occurring HIV infection and cocaine use disorder.Cognitive, affective & behavioral neuroscience · 2020Article
- Synergistic effects of marijuana abuse and HIV infection on neural activation during a cognitive interference task.Addiction biology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Stimulant abuse is disproportionately common in HIV-positive persons. Both HIV and stimulants are independently associated with deficits in reward-based decision making, but their interactive and/or additive effects are poorly understood despite their prevalent co-morbidity. Here, we examined the effects of cocaine dependence and HIV infection in 69 adults who underwent functional magnetic resonance imaging while completing an economic loss aversion task. We identified two neural networks that correlated with the evaluation of the favorable characteristics of the gamble (i.e. higher gains/lower losses: ventromedial prefrontal cortex, anterior cingulate, anterior and posterior precuneus and visual cortex) versus unfavorable characteristics of the gamble (i.e. lower gains/higher losses: dorsal prefrontal, lateral orbitofrontal, posterior parietal cortex, anterior insula and dorsal caudate). Behaviorally, cocaine and HIV had additive effects on loss aversion scores, with HIV-positive cocaine users being the least loss averse. Cocaine users had greater activation in brain regions that tracked the favorability of gamble characteristics (i.e. increased activation to gains, but decreased activation to losses). In contrast, HIV infection was independently associated with lesser activation in regions that tracked the unfavorability of gamble characteristics. These results suggest that cocaine is associated with an overactive reward-seeking system, while HIV is associated with an underactive cognitive control system. Together, these alterations may leave HIV-positive cocaine users particularly vulnerable to making unfavorable decisions when outcomes are uncertain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.