Evidence map›Paper›PMID 28681988›Full record

Trial reportDiabetes, obesity & metabolism2018

Effect of liraglutide on ectopic fat in polycystic ovary syndrome: A randomized clinical trial.

Signe Frøssing, Malin Nylander, Elizaveta Chabanova, Jan Frystyk, Jens J Holst, Caroline Kistorp, Sven O Skouby, Jens Faber

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetes, obesity & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05952882 (Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and Infertility), which is not on this map. Cited by 84 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 17 pooled it
10.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05952882 phase3unknown statusstarted 2023, after this paper: background citation

Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and Infertility

Ran2023Enrolled188Registered outcomes60Posted comparisons0ConditionsInfertility, Female, Obesity, Polycystic Ovary SyndromeArmsLiraglutide + metformin, Metformin
PMID 18364705PMID 19056992PMID 31229399PMID 29703793PMID 19841045PMID 31733195PMID 24362411PMID 31238940PMID 11527911PMID 14688154PMID 17980364PMID 18068166other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 17 syntheses or guidelines pooled it, 156 citations in OpenAlex.

  1. Pooled it
  2. Efficacy of Weight-Lowering Agents on Fat Distribution: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Glucagon-Like Peptide-1 Receptor Agonists Improve MASH and Liver Fibrosis: A Meta-Analysis of Randomised Controlled Trials.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Adipose Tissue Dysfunction in Polycystic Ovary Syndrome.The Journal of clinical endocrinology and metabolism · 2023
    Pooled it
  11. Pooled it
  12. Guideline
  13. Guideline
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Trial
  19. Trial
  20. Trial

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Signe FrøssingDepartment of Internal Medicine, Center of Endocrinology and Metabolism, Herlev Gentofte Hospital, Copenhagen, Denmark.ORCID 0000-0002-2630-1210
Malin NylanderDepartment of Obstetrics and Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark.
Elizaveta ChabanovaDepartment of Radiology, Herlev Gentofte Hospital, Copenhagen, Denmark.
Jan FrystykDepartment of Clinical Medicine, Health, Medical Research Laboratory, Aarhus University, Aarhus, Denmark.
Jens J HolstFaculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark.
Caroline KistorpDepartment of Internal Medicine, Center of Endocrinology and Metabolism, Herlev Gentofte Hospital, Copenhagen, Denmark.
Sven O SkoubyDepartment of Obstetrics and Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark.
Jens FaberDepartment of Internal Medicine, Center of Endocrinology and Metabolism, Herlev Gentofte Hospital, Copenhagen, Denmark.
University of Copenhagen · DKGentofte Hospital · DKAarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Women with polycystic ovary syndrome (PCOS) were treated with the GLP-1 receptor agonist liraglutide to investigate the effect on liver fat content, visceral adipose tissue (VAT) and the prevalence of nonalcoholic fatty liver disease (NAFLD). In a double-blind, placebo-controlled, randomized clinical trial 72 women with PCOS, with a BMI > 25 kg/m

Indexed as

Glucagon-Like Peptide-1 Receptor AgonistsAdiposityAnti-Obesity AgentsBiomarkersBody Mass IndexCohort StudiesDenmarkDouble-Blind MethodFemaleFollow-Up StudiesGlucagon-Like Peptide-1 ReceptorHumansHypoglycemic AgentsInsulin ResistanceIntra-Abdominal FatLipotropic AgentsAnti-Obesity AgentsBiomarkersGLP1R protein, humanGlucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsHypoglycemic AgentsLipotropic AgentsLiraglutidebody compositionclinical trialfatty liverGLP-1 analogueinsulin resistance

Identifiers

PMID28681988
OpenAlexW2730596924

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.