ArticleClinical endocrinology2017
Time to glucose peak during an oral glucose tolerance test identifies prediabetes risk.
Article in Clinical endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 77 citations in OpenAlex.
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- Time to Peak Glucose and Peak C-Peptide During the Progression to Type 1 Diabetes in the Diabetes Prevention Trial and TrialNet Cohorts.Diabetes care · 2021Trial
- Two- vs one-hour glucose tolerance testing: Predicting prediabetes in adolescent girls with obesity.Pediatric diabetes · 2019Trial
- Glucose curve morphology and peak time as biomarkers of metabolic health.American journal of physiology. Endocrinology and metabolism · 2026Article
- Integrated Systemic and Neurobiological Effects of a Multi-Form Magnesium Supplement Compared to Single Magnesium Forms in Rats.International journal of molecular sciences · 2026Article
- Association of the uric acid to albumin ratio with early glycemic disturbances beyond conventional OGTT criteria.BMC endocrine disorders · 2026Observational
- Associations of continuous glucose monitor derived time in range and glycaemic variability with diet lifestyle and demographics.Nature communications · 2026Article
- TheInternational journal of molecular sciences · 2025Article
- Association between early-stage diabetic nephropathy and the delayed monophasic glucose peak during oral glucose tolerance test in type 2 diabetes mellitus.Journal of diabetes investigation · 2025Observational
- Linking extent of return to fasting state after oral glucose tolerance test to future risk of prediabetes and type 2 diabetes: Insights from the TLGS.Journal of diabetes investigation · 2024Article
- Myths and methodologies: Assessing glycaemic control and associated regulatory mechanisms in human physiology research.Experimental physiology · 2024Review
- The glucose tolerance peak parameter revisited. Definition for a novel use in Gestational Diabetes Mellitus confirmation.Journal of diabetes and metabolic disorders · 2024Article
- Estimating insulin sensitivity and β-cell function from the oral glucose tolerance test: validation of a new insulin sensitivity and secretion (ISS) model.American journal of physiology. Endocrinology and metabolism · 2024Article
- Characteristics and Risk of Diabetes in People With Rare Glucose Response Curve During an Oral Glucose Tolerance Test.The Journal of clinical endocrinology and metabolism · 2024Article
- High-accuracy noninvasive continuous glucose monitoring using OCT angiography-purified blood scattering signals in human skin.Biomedical optics express · 2024Article
- Article
- Hypoglycemia and anxiolysis mediated by levofloxacin treatment in diabetic rats.Journal of diabetes and metabolic disorders · 2023Article
- Validation of Doi's weighted average glucose as a measure of post-load glucose excursion for clinical use.Biomolecules & biomedicine · 2023Article
- Assessment of glucose homeostasis in young adult female β-thalassemia major patients (β-TM) with acquired hypogonadotropic hypogonadism (AHH) never treated with sex steroids compared to eugonadal β-TM patients with spontaneous menstrual cycles.Acta bio-medica : Atenei Parmensis · 2023Article
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12 authors at 1 institution in 1 country.
Funding
Abstract
contextMorphological characteristics of the glucose curve during an oral glucose tolerance test (OGTT) (time to peak and shape) may reflect different phenotypes of insulin secretion and action, but their ability to predict diabetes risk is uncertain.
objectiveTo compare the ability of time to glucose peak and curve shape to detect prediabetes and β-cell function. DESIGN AND
participantsIn a cross-sectional evaluation using an OGTT, 145 adults without diabetes (age 42±9 years (mean±SD), range 24-62 years, BMI 29.2±5.3 kg/m
main outcome measuresPrediabetes and disposition index (DI)-a marker of β-cell function.
resultsPrediabetes was diagnosed in 36% (52/145) of participants. Peak>30 minutes, not monophasic curve, was associated with increased odds of prediabetes (OR: 4.0 vs 1.1; P<.001). Both monophasic curve and peak>30 minutes were associated with lower DI (P≤.01). Time to glucose peak and glucose area under the curves (AUC) were independent predictors of DI (adjR
conclusionGlucose peak >30 minutes was a stronger independent indicator of prediabetes and β-cell function than the monophasic curve. Time to glucose peak may be an important tool that could enhance prediabetes risk stratification.
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