Evidence map›Paper›PMID 28681901›Full record

ArticleMolecular medicine (Cambridge, Mass.)2017

Dense Genotyping of Immune-Related Regions Identifies Loci for Rheumatoid Arthritis Risk and Damage in African Americans.

Maria I Danila, Vincent Albert Laufer, Richard J Reynolds, Qi Yan, Nianjun Liu, Peter K Gregersen, Annette Lee, Marlena Kern, Carl D Langefeld, Donna K Arnett and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Genetics of rheumatoid arthritis.Seminars in immunopathology · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Identification of functional missense single-nucleotide polymorphisms inJournal of clinical and translational science · 2018
    Article
  13. Review
  14. Strong Association of Polymorphism inAvicenna journal of medical biotechnology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Maria I DanilaUniversity of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology.
Vincent Albert LauferUniversity of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology.
Richard J ReynoldsUniversity of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology.
Qi YanUniversity of Pittsburgh, Division of Pulmonary Medicine, Allergy and Immunology; Department of Pediatrics.
Nianjun LiuIndiana University School of Public Health - Bloomington, Department of Epidemiology and Biostatistics.
Peter K GregersenFeinstein Institute for Medical Research.
Annette LeeFeinstein Institute for Medical Research.
Marlena KernFeinstein Institute for Medical Research.
Carl D LangefeldWake Forest University School of Medicine.
Donna K ArnettUniversity of Kentucky College of Public Health.
S Louis BridgesUniversity of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology.
University of Alabama at Birmingham · USFeinstein Institute for Medical Research · USIndiana University Bloomington · USNorthwell Health · USUniversity of Kentucky · USUniversity of Pittsburgh · USWake Forest University · US

Funding

Training Program in Rheumatic and Musculoskeletal Diseases ResearchT32AR069516 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI John D Mountz · 2016 to 2026
$2.6M
Genetic Architecture of Rheumatoid Arthritis in African-AmericansK23AR062100 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DANILA, MARIA IOANA · 2012 to 2016
$674k
NIAMS NIH HHS K23 AR062100NIAMS NIH HHS T32 AR069516
6 · The paper itself

Abstract

Over 100 risk loci for rheumatoid arthritis (RA) have been identified in individuals of European and Asian descent, but the genetic basis for RA in African Americans is less well understood. We genotyped 610 African Americans with autoantibody positive RA and 933 African American controls on the ImmunoChip (iChip) array. Using multivariable regression we evaluated the association between iChip markers and the risk of RA and radiographic severity. The single nucleotide polymorphism (SNP) rs1964995 (OR = 1.97, p = 1.28 × 10

Indexed as

AdultAgedArthritis, RheumatoidBlack or African AmericanFemaleGenotypeHumansInterleukin-2 Receptor alpha SubunitMaleMiddle AgedNuclear ProteinsPolymorphism, Single NucleotideProto-Oncogene Protein c-ets-1RiskSeverity of Illness IndexAFF3 protein, humanETS1 protein, humanIL2RA protein, humanInterleukin-2 Receptor alpha SubunitNuclear ProteinsProto-Oncogene Protein c-ets-1aff3African Americansfine-mappinggeneticsimmunochiprheumatoid arthritistrans-ethnic

Identifiers

PMID28681901
PMCPMC5583066
OpenAlexW2752653068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.