Evidence map›Paper›PMID 28681507›Full record

ArticleBritish journal of pharmacology2017

Correlation between human ether-a-go-go-related gene channel inhibition and action potential prolongation.

P Saxena, M P Hortigon-Vinagre, S Beyl, I Baburin, S Andranovits, S M Iqbal, A Costa, A P IJzerman, P Kügler, E Timin and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. PersonalizedFrontiers in physiology · 2026
    Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

P SaxenaInstitute of Pharmacology and Toxicology, University of Vienna, Vienna, Austria.
M P Hortigon-VinagreInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
S BeylInstitute of Pharmacology and Toxicology, University of Vienna, Vienna, Austria.
I BaburinInstitute of Pharmacology and Toxicology, University of Vienna, Vienna, Austria.
S AndranovitsInstitute of Pharmacology and Toxicology, University of Vienna, Vienna, Austria.
S M IqbalInstitute of Pharmacology and Toxicology, University of Vienna, Vienna, Austria.
A CostaInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
A P IJzermanDivision of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.
P KüglerInstitute for Applied Mathematics and Statistics, University of Hohenheim, Stuttgart, Germany.
E TiminInstitute of Pharmacology and Toxicology, University of Vienna, Vienna, Austria.
G L SmithInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0003-4821-9741
S HeringInstitute of Pharmacology and Toxicology, University of Vienna, Vienna, Austria.
University of Vienna · ATGlasgow Clyde College · GBLeiden University · NLUniversity of Glasgow · GBUniversity of Hohenheim · DE

Funding

Austrian Science Fund FWF P 27729Austrian Science Fund FWF W 1232
6 · The paper itself

Abstract

background and purposeHuman ether-a-go-go-related gene (hERG; K EXPERIMENTAL APPROACH: Drug-induced changes in APD were assessed in hiPSC-CMs using voltage-sensitive dyes. The IC KEY

resultsThe D CONCLUSIONS AND IMPLICATIONS: Potency of hERG current inhibition correlates linearly with an index of APD in hiPSC-CMs. The compounds that do not correlate have additional effects including concomitant block of Ca

Indexed as

Action PotentialsCells, CulturedDose-Response Relationship, DrugEther-A-Go-Go Potassium ChannelsHEK293 CellsHumansLong QT SyndromePhenethylaminesStructure-Activity RelationshipSulfonamidesdofetilideEther-A-Go-Go Potassium ChannelsPhenethylaminesSulfonamides

Identifiers

PMID28681507
PMCPMC5573420
OpenAlexW2750648340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.