ReviewRheumatology international2018
IgG4-related disease: a complex under-diagnosed clinical entity.
Review in Rheumatology international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Effectiveness of tocilizumab monotherapy for IgG4-related disease-like features caused by idiopathic multicentric Castleman's disease: a case-based review.Rheumatology international · 2026Review
- Simultaneous improvement of immunoglobulin G4-related disease complicated by nontuberculous mycobacteria infection by anti-infective therapy alone: a case-based literature review.Rheumatology international · 2026Review
- Toward audit-ready care in IgG4-related disease: redefining relapse, damage, and access in the biologic era.Rheumatology international · 2026Article
- Comparison of Efficacy and Safety of Different Medication Protocols in Patients with Immunoglobulin G4-Related Disease Based on Follow-up Time: A Systematic Review and Network Meta-analysis.Archives of rheumatology · 2026Article
- A retrospective study on pancreatic and extra-pancreatic characteristics of IgG4-related disease.Clinical rheumatology · 2025Article
- Isolated IgG4-related prostatitis masquerading as prostate cancer: a diagnostic pitfall in patients with elevated prostate-specific antigen and prostatic mass.Rheumatology international · 2025Review
- [Blood vessels as a target organ: from Ormond's disease to immunoglobulin G4-related diseases].Innere Medizin (Heidelberg, Germany) · 2025Article
- Comparative Analysis of Clinical Characteristics in Multi-organ and Single-organ Involvement of IgG4-Related Disease: A Single-center Retrospective Study.Archives of Iranian medicine · 2025Article
- Protein Misfolding and Aggregation of Pathological IgG Light Chains in Oncohematological Dyscrasias: From Molecular Pathways to Clinical Implications.Current protein & peptide science · 2025Review
- Infrequent organ involvement in immunoglobulin G4-related prostate disease: A case report.World journal of clinical cases · 2023Article
- Serum immunoglobulin G4 has limited diagnostic value in immunoglobulin G4-related chronic rhinosinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Laboratory Investigation of Hybrid IgG4 k/λ in MuSK Positive Myasthenia Gravis.International journal of molecular sciences · 2021Article
- The Cellular and Molecular Bases of Allergy, Inflammation and Tissue Fibrosis in Patients with IgG4-related Disease.International journal of molecular sciences · 2020Review
- Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players.Journal of clinical medicine · 2020Review
- Efficacy and safety of iguratimod on patients with relapsed or refractory IgG4-related disease.Clinical rheumatology · 2020Article
- Pleural chondroid metaplasia in a background of IgG4 plasma cell rich chronic inflammatory infiltrate: report of a rare case with review of literature.Pathologica · 2019Review
- Unusual cause of pericardial effusion: IgG4-related disease.BMJ case reports · 2019Article
- IgG4-mediated autoimmune diseases: a niche of antibody-mediated disorders.Annals of the New York Academy of Sciences · 2018Review
- Challenging issues in ocular adnexal disorders.Taiwan journal of ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IgG4-related disease (IgG4-RD) encompasses a spectrum of complex fibro-inflammatory disorders which are often under diagnosed due to unfamiliarity by clinicians. A challenging multitude of clinical manifestations makes the diagnosis cumbersome. The primary clinical feature in IgG4-RD entails a tumor-like presentation coupled with tissue-destructive lesions. Histopathological findings include lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis. These findings, in combination with elevated serum immunoglobulin G4 levels, are diagnostic in the setting of single- or multi-organ involvement. A closer understanding of the role of T cells and B cells in the increased production of IgG4 has led to a notion that IgG4 can act as a pathogen, anti-inflammatory agent, or rheumatoid factor. Glucocorticoids are the primary treatment modality; however, relapse is common with prolonged therapy. Alternatively, immunomodulatory agents are being increasingly used as therapy. The aim of this article is to raise awareness of IgG4-RD and review the diagnostic algorithm, as IgG4-RD often mimics a wide array of clinical conditions. In addition, we summarize the pathogenesis and current treatment guidelines of IgG4-RD for clinicians. Awareness and accurate diagnosis are crucial in preventing progression to chronic diseases, thereby diminishing disease-related morbidity and mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.