Evidence map›Paper›PMID 28681248›Full record

ArticleClinical oral investigations2018

Sinus floor elevation using implants coated with recombinant human bone morphogenetic protein-2: micro-computed tomographic and histomorphometric analyses.

Daniel S Thoma, So-Ra Yoon, Jae-Kook Cha, Hyun-Chang Lim, Jung-Seok Lee, Seong-Ho Choi, Ui-Won Jung

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Daniel S ThomaClinic for Fixed and Removable Prosthodontics and Dental Material Science, University of Zurich, Zurich, Switzerland.
So-Ra YoonDepartment of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
Jae-Kook ChaDepartment of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
Hyun-Chang LimDepartment of Periodontology, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea.
Jung-Seok LeeDepartment of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
Seong-Ho ChoiDepartment of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
Ui-Won JungDepartment of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea. drjew@yuhs.ac.ORCID http://orcid.org/0000-0001-6371-4172
Yonsei University · KRKyung Hee University · KRUniversity of Zurich · CH

Funding

the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science, ICT & Future Planning) NRF-2017R1A2B2002537
6 · The paper itself

Abstract

objectivesThe objective of this study was to determine the validity of a graft-free sinus floor elevation (SFE) procedure with simultaneous placement of recombinant morphogenetic protein-2 (rhBMP-2)-coated implants compared to uncoated control implants.

methodsIn 10 rabbits, SFE was performed on both sides. Dental implants were randomly placed in the sinus filled with a blood clot. Test implants were coated with rhBMP-2, whereas in the control group, implants were uncoated. Micro-computed tomographic and histomophometric analyses were performed at 4 and 8 weeks, including measurement for newly formed bone height (NBHm).

resultsBone formation was evident along the implant surfaces up to the apex in test, but limited in control implants at 4 weeks. NBHm amounted to 5.1 mm (Q1 = 4.1; Q3 = 5.3) for test implants and to 3.4 mm (2.6; 3.7) for control implants at 4 weeks. NBHm then decreased to 8 weeks (3.4 mm (3.3; 3.7)) for test implants, whereas in control sites, NBHm increased slightly to 4.4 mm (4.1; 4.5) (p = 0.1250; p = 0.6250).

conclusionsImplants coated with rhBMP-2 presented a strong osteogenic reaction at 4 weeks with more favorable outcomes in terms of bone formation along the implant surface up to the apex compared to uncoated control implants. Remodeling and resorption process between 4 and 8 weeks did not further improve the outcomes in the test, but in the control group. CLINICAL RELEVANCE: The use of rhBMP-2-coated implants in a graft-free SFE might show an advantage in early implant stability to prevent collapse of membrane. However, a potential clinical benefit still needs to be proven.

Indexed as

Dental ImplantsX-Ray MicrotomographyAnimalsBone Morphogenetic Protein 2Coated Materials, BiocompatibleDental Implantation, EndosseousDental Prosthesis DesignHumansImplants, ExperimentalMaleOsteogenesisRabbitsRecombinant ProteinsSinus Floor AugmentationTransforming Growth Factor betaBone Morphogenetic Protein 2Coated Materials, BiocompatibleDental Implantsrecombinant human bone morphogenetic protein-2Recombinant ProteinsTransforming Growth Factor betaAnimal studyBone morphogenetic protein-2Dental implantHistologyMaxillary sinus augmentationMicro-computed tomography

Identifiers

PMID28681248
OpenAlexW2733293766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.