Evidence map›Paper›PMID 28681201›Full record

ReviewTransgenic research2017

Gene editing tools: state-of-the-art and the road ahead for the model and non-model fishes.

Hirak Kumar Barman, Kiran Dashrath Rasal, Vemulawada Chakrapani, A S Ninawe, Doyil T Vengayil, Syed Asrafuzzaman, Jitendra K Sundaray, Pallipuram Jayasankar

Abstract readReview
PubMed Publisher
In one paragraph

Review in Transgenic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Advancements in genetic studies of mushrooms: a comprehensive review.World journal of microbiology & biotechnology · 2024
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Gene Therapy in Hemophilia: Recent Advances.International journal of molecular sciences · 2021
    Review
  8. Developmental constraints on fin diversity.Development, growth & differentiation · 2020
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hirak Kumar BarmanFish Genetics and Biotechnology Division, ICAR - Central Institute of Freshwater Aquaculture, Bhubaneswar, Odisha, 751002, India. hkbarman68@hotmail.com.
Kiran Dashrath RasalFish Genetics and Biotechnology Division, ICAR - Central Institute of Freshwater Aquaculture, Bhubaneswar, Odisha, 751002, India.
Vemulawada ChakrapaniFish Genetics and Biotechnology Division, ICAR - Central Institute of Freshwater Aquaculture, Bhubaneswar, Odisha, 751002, India.
A S NinaweDepartment of Biotechnology, Ministry of Science and Technology, CGO Complex, Block 3, Lodhi Road, New Delhi, 110003, India.
Doyil T VengayilScience and Engineering Research Board (SERB), 5 and 5A, Lower Ground Floor, Vasant Square Mall, Sector-B, Pocket - 5, Vasantkunj, New Delhi, 110 070, India.
Syed AsrafuzzamanScience and Engineering Research Board (SERB), 5 and 5A, Lower Ground Floor, Vasant Square Mall, Sector-B, Pocket - 5, Vasantkunj, New Delhi, 110 070, India.
Jitendra K SundarayFish Genetics and Biotechnology Division, ICAR - Central Institute of Freshwater Aquaculture, Bhubaneswar, Odisha, 751002, India.
Pallipuram JayasankarFish Genetics and Biotechnology Division, ICAR - Central Institute of Freshwater Aquaculture, Bhubaneswar, Odisha, 751002, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advancements in the DNA sequencing technologies and computational biology have revolutionized genome/transcriptome sequencing of non-model fishes at an affordable cost. This has led to a paradigm shift with regard to our heightened understandings of structure-functional relationships of genes at a global level, from model animals/fishes to non-model large animals/fishes. Whole genome/transcriptome sequencing technologies were supplemented with the series of discoveries in gene editing tools, which are being used to modify genes at pre-determined positions using programmable nucleases to explore their respective in vivo functions. For a long time, targeted gene disruption experiments were mostly restricted to embryonic stem cells, advances in gene editing technologies such as zinc finger nuclease, transcriptional activator-like effector nucleases and CRISPR (clustered regulatory interspaced short palindromic repeats)/CRISPR-associated nucleases have facilitated targeted genetic modifications beyond stem cells to a wide range of somatic cell lines across species from laboratory animals to farmed animals/fishes. In this review, we discuss use of different gene editing tools and the strategic implications in fish species for basic and applied biology research.

Indexed as

AnimalsCRISPR-Cas SystemsFishesGene EditingGenetic EngineeringModels, AnimalAquacultureCRISPR/Cas9Genome editingTALENZFN

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.