ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2017
TLR4 regulates insulin-resistant proteins to increase apoptosis in the mouse retina.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Fetuin-B Interacts With Insulin Receptor-β and Promotes Insulin Resistance in Retina Cells.Investigative ophthalmology & visual science · 2024Article
- Ocular manifestations of central insulin resistance.Neural regeneration research · 2023Article
- Toll-Like Receptor Signalling Pathways and the Pathogenesis of Retinal Diseases.Frontiers in ophthalmology · 2022Review
- MiR-17 family-mediated regulation of Pknox1 influences hepatic steatosis and insulin signaling.Journal of cellular and molecular medicine · 2018Article
- HMGB1 inhibits insulin signalling through TLR4 and RAGE in human retinal endothelial cells.Growth factors (Chur, Switzerland) · 2018Article
- Inhibition of Expression of the S100A8 Gene Encoding the S100 Calcium-Binding Protein A8 Promotes Apoptosis by Suppressing the Phosphorylation of Protein Kinase B (Akt) in Endometrial Carcinoma and HEC-1A Cells.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Toll-like receptor 4 regulates insulin signal transduction in retinal Müller cells.Growth factors (Chur, Switzerland) · 2017Article
- Toll-Like Receptor 4 Reduces Occludin and Zonula Occludens 1 to Increase Retinal Permeability Both in vitro and in vivo.Journal of vascular research · 2017Article
- Loss of TLR4 in mouse Müller cells inhibits both MyD88-dependent and -independent signaling.PloS one · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
OBJECTIVE AND
designWork in multiple organs has suggested that toll-like receptor 4 (TLR4) may play a role in insulin resistance. Additional studies have shown a negative role for TLR4 on retinal health. We have previously reported that β-adrenergic receptors can regulate both TLR4 signal transduction, as well as insulin signaling in the retina and in retinal endothelial cells. Thus, we hypothesized that TLR4 would regulate retinal insulin signaling. MATERIALS AND
methodsWe used endothelial cell-specific TLR4 knockout mice, as well as TLR4-overexpressing mice for these studies.
methodsWestern blotting and ELISA analyses were done for investigations of insulin receptor, insulin receptor substrate 1 (IRS-1) serine 307, and Akt phosphorylation, as well as cleaved caspase 3 levels in the mouse retina.
resultsWe found that loss of TLR4 led to increased insulin receptor and Akt phosphorylation, as well as decreased IRS-1
conclusionsTherefore, these results suggest that TLR4 plays a key role in insulin signaling in the retina. Reduction of TLR4 levels may be protective to the retina.
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Registered trials
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