ReviewExtremophiles : life under extreme conditions2017
Structure and mechanisms of viral transcription factors in archaea.
Review in Extremophiles : life under extreme conditions, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Unraveling the diversity, function, and virus-host interactions of archaeal proviruses.ISME communications · 2026Article
- Characterization of archaeal promoters using explainable and web-based CNN model.BMC genomics · 2025Article
- Diversity ofISME communications · 2024Article
- How to Shut Down Transcription in Archaea during Virus Infection.Microorganisms · 2022Review
- Structural basis of RNA polymerase inhibition by viral and host factors.Nature communications · 2021Article
- Evolution of Regulated Transcription.Cells · 2020Review
- The cutting edge of archaeal transcription.Emerging topics in life sciences · 2018Article
- Structure and function of archaeal histones.PLoS genetics · 2018Review
- A transcriptional factor B paralog functions as an activator to DNA damage-responsive expression in archaea.Nucleic acids research · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Virus-encoded transcription factors have been pivotal in exploring the molecular mechanisms and regulation of gene expression in bacteria and eukaryotes since the birth of molecular biology, while our understanding of viral transcription in archaea is still in its infancy. Archaeal viruses do not encode their own RNA polymerases (RNAPs) and are consequently entirely dependent on their hosts for gene expression; this is fundamentally different from many bacteriophages and requires alternative regulatory strategies. Archaeal viruses wield a repertoire of proteins to expropriate the host transcription machinery to their own benefit. In this short review we summarise our current understanding of gene-specific and global mechanisms that viruses employ to chiefly downregulate host transcription and enable the efficient and temporal expression of the viral transcriptome. Most of the experimentally characterised archaeo-viral transcription regulators possess either ribbon-helix-helix or Zn-finger motifs that allow them to engage with the DNA in a sequence-specific manner, altering the expression of a specific subset of genes. Recently a novel type of regulator was reported that directly binds to the RNAP and shuts down transcription of both host and viral genes in a global fashion.
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