ArticlePediatric nephrology (Berlin, Germany)2017
Urinary tract infection in small children: the evolution of renal damage over time.
Article in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Evidence-based clinical practice guideline for management of urinary tract infection and primary vesicoureteric reflux.Pediatric nephrology (Berlin, Germany) · 2024Guideline
- Effectiveness of various treatment modalities in children with vesicoureteral reflux grades II-IV: a systematic review and network meta-analysis.BMJ paediatrics open · 2023Pooled it
- Effectiveness of ertapenem for treatment of infections in children: An evidence mapping and meta-analysis.Frontiers in pediatrics · 2022Pooled it
- Critical evaluation of arguments opposing male circumcision: A systematic review.Journal of evidence-based medicine · 2019Pooled it
- Dexamethasone to prevent kidney scarring in acute pyelonephritis: a randomized clinical trial.Pediatric nephrology (Berlin, Germany) · 2022Trial
- Circumcision and continuous antibiotic prophylaxis in preventing recurrent febrile urinary tract infection in boys with high-grade vesicoureteral reflux.Jornal de pediatria · 2026Article
- Development of a machine learning model for predicting renal damage in children with closed spinal dysraphism.BMC pediatrics · 2025Article
- Molecular analysis of acute pyelonephritis-excessive innate and attenuated adaptive immunity.Life science alliance · 2025Article
- Infant urinary tract infection in Sweden - A national study of current diagnostic procedures, imaging and treatment.Pediatric nephrology (Berlin, Germany) · 2024Article
- Genetic determinants of renal scarring in children with febrile UTI.Pediatric nephrology (Berlin, Germany) · 2024Article
- Concentration of novel urinary tract infection biomarkers in neonates.Scientific reports · 2024Article
- Neonatal Male Circumcision: Clearly Beneficial for Public Health or an Ethical Dilemma? A Systematic Review.Cureus · 2024Review
- Acute pyelonephritis in children and the risk of end-stage kidney disease.Journal of nephrology · 2021Article
- Molecular determinants of disease severity in urinary tract infection.Nature reviews. Urology · 2021Review
- Vesicoureteral reflux is it important to find?Pediatric nephrology (Berlin, Germany) · 2021Review
- Management of Vesicoureteral Reflux: What Have We Learned Over the Last 20 Years?Frontiers in pediatrics · 2021Review
- Urine neutrophil gelatinase-associated lipocalin in girls with recurrent urinary tract infections.Pediatric nephrology (Berlin, Germany) · 2020Article
- The role of bladder function in the pathogenesis and treatment of urinary tract infections in toilet-trained children.Pediatric nephrology (Berlin, Germany) · 2020Review
- Predictors of grade 3-5 vesicoureteral reflux in infants ≤ 2 months of age with pyelonephritis.Pediatric nephrology (Berlin, Germany) · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur objective was to analyze the evolution of kidney damage over time in small children with urinary tract infection (UTI) and factors associated with progression of renal damage.
methodsFrom a cohort of 1003 children <2 years of age with first-time UTI, a retrospective analysis of 103 children was done. Children were selected because of renal damage at index
resultsOf 103 children, 20 showed progression, 20 regression, and 63 remained unchanged. There were no differences between groups regarding gender or age. In the progression group, 16/20 (80%) children had vesicoureteral reflux (VUR) grade III-V and 13 (65%) had recurrent UTI. In multivariable regression analysis, both VUR grade III-V and recurrent UTI were associated with progression. In the regression group, 16/20 (80%) had no VUR or grade I-II, and two (10%) had recurrent UTI.
conclusionsMost small children with febrile UTI do not develop renal damage and if they do the majority remain unchanged or regress over time. However, up to one-fifth of children with renal damage diagnosed after UTI are at risk of renal deterioration. These children are characterized by the presence of VUR grades III-V and recurrent febrile UTI and may benefit from follow-up.
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