ArticleNeurology(R) neuroimmunology & neuroinflammation2017
Antiepileptic drug therapy in patients with autoimmune epilepsy.
Article in Neurology(R) neuroimmunology & neuroinflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Anticonvulsive treatment in autoimmune encephalitis: a systematic literature review.Wiener medizinische Wochenschrift (1946) · 2024Pooled it
- Autoimmune encephalitis during pregnancy: A diagnostic and therapeutic challenge-A systematic review with individual patients' analysis and clinical recommendations.Epilepsia open · 2023Pooled it
- Evaluation of Retinal Histological Alterations Following Carbamazepine Administration in Adult Albino Wistar Rats.Cureus · 2026Article
- Choroid Plexus Abnormalities in Autoimmune Encephalitis.CNS neuroscience & therapeutics · 2026Article
- Characteristics of and risk factors for epilepsy after autoimmune and infectious encephalitis.BMC neurology · 2026Article
- Predictive value of persistent cerebrospinal fluid antibodies at 12 months for long-term clinical outcomes in pediatric anti-NMDAR encephalitis: a retrospective cohort study.Frontiers in immunology · 2026Observational
- Autoimmune encephalitis.Nature reviews. Disease primers · 2025Review
- Daidzin Enhances the Anticonvulsion Effects of Carbamazepine and Diazepam, Possibly Through Voltage-Gated Sodium Channels and GABAMolecular neurobiology · 2025Article
- Autoimmune encephalitis-associated epilepsy.Nature reviews. Neurology · 2025Review
- Enigmatic intractable Epilepsy patients have antibodies that bind glutamate receptor peptides, kill neurons, damage the brain, and cause Generalized Tonic Clonic Seizures.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Prodromal seizures in anti-MOG and anti-CASPR2 antibody co-positivity: a case report.Journal of neurology · 2025Article
- Diagnostic Significance of Paraneoplastic Neuronal Antibodies in Japanese Adults with Autoimmune Encephalitis: A Case Series Study in an Adult Epilepsy Clinic.Clinical pharmacology : advances and applications · 2025Article
- Efficacy of add-on Cenobamate treatment in refractory epilepsy due to Rasmussen's encephalitis.Epilepsia open · 2024Article
- Case report: Refractory focal motor seizure associated with cerebrospinal fluid neurochondrin antibody.Frontiers in immunology · 2024Article
- Assessment of Prognostic Factors and Validity of Scoring Models in Childhood Autoimmune Encephalitis.Turkish archives of pediatrics · 2023Article
- Seizures, Epilepsy, and NORSE Secondary to Autoimmune Encephalitis: A Practical Guide for Clinicians.Biomedicines · 2022Review
- Article
- Severity of Epilepsy and Response to Antiseizure Medications in Individuals With Multiple Sclerosis: Analysis of a Real-World Dataset.Neurology. Clinical practice · 2022Article
- Factors Influencing the Withdrawal of Antiepileptic Drugs in Adult Patients with Symptomatic Seizures Secondary to Neuronal Surface Antibodies-Associated Autoimmune Encephalitis.Journal of inflammation research · 2022Article
- Characterization of cardiac bradyarrhythmia associated with LGI1-IgG autoimmune encephalitis.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to report the pattern of usage and efficacy of antiepileptic drugs (AEDs) in patients with autoimmune epilepsy (AE).
methodsWe retrospectively studied the Mayo Clinic's electronic medical record of patients with AE in which seizures were the main presenting feature. Clinical data, including demographics, seizure characteristics, type of AED and immunotherapy used, presence of neural antibody, and treatment outcomes, were reviewed.
resultsThe medical records of 252 adult patients diagnosed with autoimmune encephalitis and paraneoplastic disorders were reviewed. Seizure was the initial presentation in 50 patients (20%). Serum and/or CSF autoantibodies were detected in 41 (82%) patients, and 38 (76%) patients had neural autoantibodies. The majority (n = 43, 86%) received at least 1 form of immunotherapy in combination with AEDs, while the remainder received AEDs alone. Twenty-seven patients (54%) became seizure free: 18 (36%) with immunotherapy, 5 (10%) with AEDs alone, and 4 (8%) with AEDs after immunotherapy failure. Levetiracetam was the most commonly used (42/50); however, it was associated with 0% seizure-free response. AED seizure-free responses occurred with carbamazepine (n = 3) [3/16, 18.8%], lacosamide (n = 3) [3/18, 16.6%] with phenytoin (n = 1) [1/8, 12.5%], or oxcarbazepine (n = 2) [2/11, 18.1%]. Regardless of the type of therapy, voltage-gated potassium channel-complex antibody-positive patients were more likely to become seizure free compared with glutamic acid decarboxylase 65 antibody-positive cases (12/17 vs 2/10,
conclusionsIn select patients, AEDs alone were effective in controlling seizures. AEDs with sodium channel blocking properties resulted in seizure freedom in a few cases. Prospective studies are needed to clarify AED selection and to elucidate their immunomodulatory properties in AE.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.