ArticleFrontiers in cellular and infection microbiology2017
Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms.
Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Genomic and phenotypic insights into the novel speciesMicrobiology spectrum · 2026Article
- Activation of cellular responses by cyclic dinucleotides andJournal of oral microbiology · 2025Article
- Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulation.Frontiers in microbiology · 2025Review
- [Research Progress on Drug Intervention to Inhibit Dental Plaque Biofilm Formation bySichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Review
- Tissue specific innate immune responses impact viral infection in Drosophila.PLoS pathogens · 2024Article
- Virtual Screening of Inhibitors ofACS medicinal chemistry letters · 2024Article
- The Many Ways to Deal with STING.International journal of molecular sciences · 2023Review
- Cyclic di-adenosine monophosphate regulates the osteogenic and adipogenic differentiation of hPDLSCs via MAPK and NF-κB signaling.Acta biochimica et biophysica Sinica · 2023Article
- Ebselen Optimized the Therapeutic Effects of Silver Nanoparticles for Periodontal Treatment.International journal of nanomedicine · 2023Article
- Atypical cyclic di-AMP signaling is essential for Porphyromonas gingivalis growth and regulation of cell envelope homeostasis and virulence.NPJ biofilms and microbiomes · 2022Article
- Dental caries and periodontitis risk factors in cleft lip and palate patients.Frontiers in pediatrics · 2022Review
- Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP.Journal of oral microbiology · 2022Article
- Bacterial Cyclic Dinucleotides and the cGAS-cGAMP-STING Pathway: A Role in Periodontitis?Pathogens (Basel, Switzerland) · 2021Review
- The oralome and its dysbiosis: New insights into oral microbiome-host interactions.Computational and structural biotechnology journal · 2021Review
- Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide.Pathogens (Basel, Switzerland) · 2020Article
- Metatranscriptomic analysis of anJournal of oral microbiology · 2019Article
- Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides.Journal of oral microbiology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral cavity acts as a reservoir of bacterial pathogens for systemic infections and several oral microorganisms have been linked to systemic diseases. Quorum sensing and cyclic dinucleotides, two "decision-making" signaling systems, communicate to regulate physiological process in bacteria. Discovery of cyclic dinucleotides has a long history, but the progress in our understanding of how cyclic dinucleotides regulate bacterial lifestyle is relatively new. Oral microorganisms form some of the most intricate biofilms, yet c-di-GMP, and c-di-AMP signaling have been rarely studied in oral biofilms. Recent studies demonstrated that, with the aid of bacterial messenger molecules and their analogs, it is possible to activate host innate and adaptive immune responses and epithelial integrity with a dose that is relevant to inhibit bacterial virulence mechanisms, such as fimbriae and exopolysaccharide production, biofilm formation, and host cell invasion. The aim of this perspective article is to present available information on cyclic dinucleotides in oral bacteria and in oral biofilms. Moreover, technologies that can be used to detect cyclic dinucleotides in oral biofilms are described. Finally, directions for future research are highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.