ReviewKidney research and clinical practice2017
A unified pathogenesis for kidney diseases, including genetic diseases and cancers, by the protein-homeostasis-system hypothesis.
Review in Kidney research and clinical practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Infectious triggers in IgA vasculitis in children: current evidence, causal attribution and immunopathogenic mechanisms.Rheumatology international · 2026Review
- Association of Conicity Index and Abdominal Volume Index with Handgrip Strength and Quality of Life in Hemodialysis Patients: Evidence from a Cross-Sectional Study.International journal of preventive medicine · 2026Article
- An etiopathogenesis of juvenile idiopathic arthritis: the protein-homeostasis-system hypothesis.Frontiers in pediatrics · 2026Review
- A new immunological paradigm for diseases: the protein-homeostasis-system hypothesis.Frontiers in immunology · 2026Review
- A Unified Pathogenesis of Allergic Diseases; The Protein-Homeostasis-System Hypothesis.International journal of molecular sciences · 2025Review
- Is there any association between type of dietary fat and quality of life in hemodialysis patients? A cross-sectional study.Frontiers in nutrition · 2024Article
- Common immunopathogenesis of central nervous system diseases: the protein-homeostasis-system hypothesis.Cell & bioscience · 2022Review
- Etiological and pathophysiological enigmas of severe coronavirus disease 2019, multisystem inflammatory syndrome in children, and Kawasaki disease.Clinical and experimental pediatrics · 2022Article
- Immunopathogenesis of COVID-19 and early immunomodulators.Clinical and experimental pediatrics · 2020Article
- Early preemptive immunomodulators (corticosteroids) for severe pneumonia patients infected with SARS-CoV-2.Clinical and experimental pediatrics · 2020Article
- Kawasaki Disease Following Severe Sunburn Injury.Frontiers in pediatrics · 2020Article
- White Blood Cell and Neutrophil Counts and Response to Intravenous Immunoglobulin in Kawasaki Disease.Global pediatric health · 2019Article
- A Presumed Etiology of Kawasaki Disease Based on Epidemiological Comparison With Infectious or Immune-Mediated Diseases.Frontiers in pediatrics · 2019Article
- Dialysis: A Review of the Mechanisms Underlying Complications in the Management of Chronic Renal Failure.Cureus · 2017Review
- Article
- "Machine-Dependent": The Lived Experiences of Patients Receiving Hemodialysis in Pakistan.Global qualitative nursing researchArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Every cell of an organism is separated and protected by a cell membrane. It is proposed that harmony between intercellular communication and the health of an organism is controlled by a system, designated the protein-homeostasis-system (PHS). Kidneys consist of a variety of types of renal cells, each with its own characteristic cell-receptor interactions and producing characteristic proteins. A functional union of these renal cells can be determined by various renal function tests, and harmonious intercellular communication is essential for the healthy state of the host. Injury to a kind of renal cells can impair renal function and induce an imbalance in total body health. Every acute or chronic renal disease has unknown etiologic substances that are responsible for renal cell injury at the molecular level. The immune/repair system of the host should control the etiologic substances acting against renal cells; if this system fails, the disease progresses to end stage renal disease. Each renal disease has its characteristic pathologic lesions where immune cells and immune proteins, such as immunoglobulins and complements, are infiltrated. These immune cells and immune proteins may control the etiologic substances involved in renal pathologic lesions. Also, genetic renal diseases and cancers may originate from a protein deficiency or malfunctioning protein under the PHS. A unified pathogenesis for renal diseases, including acute glomerulonephritis, idiopathic nephrotic syndrome, immunoglobulin A nephropathy, genetic renal diseases such as Alport syndrome, and malignancies such as Wilms tumor and renal cell carcinoma, is proposed using the PHS hypothesis.
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