Evidence map›Paper›PMID 28680760›Full record

ArticleOncoimmunology

Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment.

Aliyah M Weinstein, Lu Chen, Emily A Brzana, Prashanti R Patil, Jennifer L Taylor, Kellsye L Fabian, Callen T Wallace, Sabrina D Jones, Simon C Watkins, Binfeng Lu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
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  11. Tertiary lymphoid structures and their therapeutic implications in cancer.Cellular oncology (Dordrecht, Netherlands) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Aliyah M WeinsteinDepartment of Immunology, University of Pittsburgh School of Medicine (UPSOM), Pittsburgh, PA, USA.
Lu ChenDepartment of Immunology, University of Pittsburgh School of Medicine (UPSOM), Pittsburgh, PA, USA.
Emily A BrzanaDepartment of Dermatology, UPSOM, Pittsburgh, PA, USA.
Prashanti R PatilDepartment of Dermatology, UPSOM, Pittsburgh, PA, USA.
Jennifer L TaylorDepartment of Dermatology, UPSOM, Pittsburgh, PA, USA.
Kellsye L FabianDepartment of Immunology, University of Pittsburgh School of Medicine (UPSOM), Pittsburgh, PA, USA.
Callen T WallaceDepartment of Cell Biology and Physiology, UPSOM, Pittsburgh, PA, USA.
Sabrina D JonesDepartment of Dermatology, UPSOM, Pittsburgh, PA, USA.
Simon C WatkinsDepartment of Cell Biology and Physiology, UPSOM, Pittsburgh, PA, USA.
Binfeng LuDepartment of Immunology, University of Pittsburgh School of Medicine (UPSOM), Pittsburgh, PA, USA.
David F StroncekDepartment of Transfusion Medicine, Clinical Center, NIH, Bethesda, PA, USA.
Timothy L DenningCenter for Inflammation, Immunity & Infection at Georgia State University, Atlanta, GA, USA.
Yang-Xin FuDepartments of Pathology and Immunology, UT Southwestern Medical Center, Dallas, TX, USA.
Peter A CohenDepartment of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ, USA.
Walter J StorkusDepartment of Immunology, University of Pittsburgh School of Medicine (UPSOM), Pittsburgh, PA, USA.
University of Pittsburgh · USGeorgia State University · USMayo Clinic in Arizona · USSouthwestern Medical Center · US

Funding

Induction of Therapeutic Immunity in the Tumor MicroenvironmentR01CA204419 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STORKUS, WALTER J. · 2016 to 2020
$1.7M
Develop novel assays for assessing cellular and gene therapiesZIACL002119 · CLC · CLINICAL CENTER · PI STRONCEK, DAVID · 2010 to 2025
$0k
NCI NIH HHS R01 CA204419
6 · The paper itself

Abstract

We have previously reported that direct injection of dendritic cells (DC) engineered to express the Type-1 transactivator Tbet (i.e., DC.Tbet) into murine tumors results in antitumor efficacy in association with the development of structures resembling tertiary lymphoid organs (TLO) in the tumor microenvironment (TME). These TLO contained robust infiltrates of B cells, DC, NK cells, and T cells in proximity to PNAd

Indexed as

Dendritic cellsimmunotherapyinterleukin (IL)-36γtbettertiary lymphoid organtumor

Identifiers

PMID28680760
PMCPMC5486180
OpenAlexW2608885960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.