Evidence map›Paper›PMID 28680744›Full record

ArticleOncoimmunology

Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4

Zuqiang Liu, Xingxing Hao, Yi Zhang, Jiying Zhang, Cara D Carey, Louis D Falo, Walter J Storkus, Zhaoyang You

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Zuqiang LiuDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-4181-8103
Xingxing HaoDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-8464-2304
Yi ZhangDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jiying ZhangDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Cara D CareyDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Louis D FaloDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Walter J StorkusDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Zhaoyang YouDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
University of Pittsburgh · US

Funding

Tumor Cell-derived HMGB1-initiated Activation of TregR21CA191522 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YOU, ZHAOYANG · 2015 to 2016
$359k
NCI NIH HHS R21 CA191522
6 · The paper itself

Abstract

The progressive tumor microenvironment (TME) coordinately supports tumor cell expansion and metastasis, while it antagonizes the survival and (poly-)functionality of antitumor T effector cells. There remains a clear need to develop novel therapeutic strategies that can transform the TME into a pro-inflammatory niche that recruits and sustains protective immune cell populations. While intravenous treatment with tumor-primed CD4

Indexed as

Cancer immunotherapytumor microenvironmentvaccine

Identifiers

PMID28680744
PMCPMC5486177
OpenAlexW2608520162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.