ArticleJournal of periodontal & implant science2017
Periodontal and endodontic pathology delays extraction socket healing in a canine model.
Article in Journal of periodontal & implant science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- The Peridental Structures of Equine Cheek Teeth: An Age-Dependent Anatomical Study of Maxilla and Mandible.Animals : an open access journal from MDPI · 2026Article
- Lpar3-mediated macrophage polarization promotes inflammatory tooth extraction socket healing and alveolar bone regeneration.Regenerative therapy · 2026Article
- Alveolar Ridge Preservation Revisited: A Multimodal Evaluation of Bone Preservation and Regeneration-Preliminary Findings from a Randomized Controlled Clinical Trial.Bioengineering (Basel, Switzerland) · 2026Article
- Jawbone Cavitations: Current Understanding and Conceptual Introduction of Covered Socket Residuum (CSR).Bioengineering (Basel, Switzerland) · 2026Review
- Greater bone regeneration required for implants following periodontal extraction: a retrospective cross-sectional study.BMC oral health · 2025Observational
- Correlation between newly formed bone and the progression of experimental peri-implantitis with or without alveolar ridge preservation in infected and non-infected teeth: a secondary analysis of a preclinical study.Journal of periodontal & implant science · 2025Article
- Does defect configuration affect the outcomes of alveolar ridge preservation? An experimentalJournal of periodontal & implant science · 2025Article
- Effectiveness of a Nanohydroxyapatite-Based Hydrogel on Alveolar Bone Regeneration in Post-Extraction Sockets of Dogs with Naturally Occurring Periodontitis.Veterinary sciences · 2021Article
- Effect of ridge preservation at molar extraction sites with severe periodontitis on the Schneiderian membrane thickness changes: a pilot study.BMC oral health · 2021Article
- Endodontic remnants are found more than other radiopacities in proposed implant sites.International journal of implant dentistry · 2021Article
- Compromised extraction sockets: a new classification and prevalence involving both soft and hard tissue loss.Journal of periodontal & implant science · 2021Article
- Natural Tooth Pontic Using Recent Adhesive Technologies: An Esthetic and Minimally Invasive Prosthetic Solution.Case reports in dentistry · 2020Article
- Alveolar bone healing in rats: micro-CT, immunohistochemical and molecular analysis.Journal of applied oral science : revista FOB · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the present exploratory study was to evaluate extraction socket healing at sites with a history of periodontal and endodontic pathology.
methodsThe mandibular 4th premolar teeth in 5 adult beagle dogs served as experimental units. Periodontal and endodontic lesions were induced in 1 premolar site in each animal using wire ligatures and pulpal exposure over 3 months (diseased sites). The contralateral premolar sites served as healthy controls. The mandibular 4th premolar teeth were then extracted with minimal trauma, followed by careful wound debridement. The animals were sacrificed at days 1, 7, 30, 60, and 90 post-extraction for analysis, and the healing patterns at the healthy and diseased extraction sites were compared using radiography, scanning electron microscopy, histology, and histometry.
resultsDuring the first 7 days of healing, a significant presence of inflammatory granulation tissue was noted at the diseased sites (day 1), along with a slightly accelerated rate of fibrin clot resolution on day 7. On day 30, the diseased extraction sites showed a greater percentage of persistent fibrous connective tissue, and an absence of bone marrow formation. In contrast, healthy sites showed initial signs of bone marrow formation on day 30, and subsequently a significantly greater proportion of mature bone marrow formation on both days 60 and 90. Radiographs exhibited sclerotic changes adjoining apical endodontic lesions, with scanning electron microscopy showing collapsed Volkmann canals protruding from these regions in the diseased sites. Furthermore, periodontal ligament fibers exhibited a parallel orientation to the alveolar walls of the diseased sites, in contrast to a perpendicular arrangement in the healthy sites.
conclusionsWithin the limitations of this study, it appears that a history of periodontal and endodontic pathology may critically affect bone formation and maturation, leading to delayed and compromised extraction socket healing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.