ArticleRoyal Society open science2017
Proteomic profiling of archaeological human bone.
Article in Royal Society open science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Proteomic profiling of bone for the estimation of post-mortem interval and post-mortem submersion interval: a systematic review.International journal of legal medicine · 2026Pooled it
- Forensic applications of postmortem protein analysis in estimating the time since death: a systematic review.International journal of legal medicine · 2026Pooled it
- Extracellular matrix composition of connective tissues: a systematic review and meta-analysis.Scientific reports · 2019Pooled it
- Assessing the Potential of Ancient Protein Sequences in the Study of Hominid Evolution.Genome biology and evolution · 2026Article
- The Japanese Archipelago sheltered cave lions, not tigers, during the Late Pleistocene.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Identification and removal of contamination in palaeoproteomic analysis of dental enamel.Scientific reports · 2025Article
- Identification of typical marker proteins of Treponema pallidum in compact human bone using morphological and biochemical techniques.Scientific reports · 2025Article
- Proteomic Investigation of Human Dental Pulp to Identify Individuals Who Are Pregnant.Proteomics. Clinical applications · 2025Article
- Evidence for Endogenous Collagen inAnalytical chemistry · 2025Article
- Paleoproteomic identification of the species used in fourteenth century gut-skin garments from the archaeological site of Nuulliit, Greenland.Scientific reports · 2024Article
- Sequential trypsin and ProAlanase digestions unearth immunological protein biomarkers shrouded by skeletal collagen.iScience · 2024Article
- Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus.Scientific reports · 2024Article
- Comparing extraction method efficiency for high-throughput palaeoproteomic bone species identification.Scientific reports · 2023Article
- Proteomic identification of beer brewing products in the ground layer of Danish Golden Age paintings.Science advances · 2023Article
- Paleoproteomics.Chemical reviews · 2022Review
- Palaeoproteomics guidelines to identify proteinaceous binders in artworks following the study of a 15th-century painting by Sandro Botticelli's workshop.Scientific reports · 2022Article
- Molecular signatures written in bone proteins of 79 AD victims from Herculaneum and Pompeii.Scientific reports · 2022Article
- Insights into the Differential Preservation of Bone Proteomes in Inhumed and Entombed Cadavers from Italian Forensic Caseworks.Journal of proteome research · 2022Article
- Faecal proteomics as a novel method to study mammalian behaviour and physiology.Molecular ecology resources · 2021Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ancient protein analysis provides clues to human life and diseases from ancient times. Here, we performed shotgun proteomics of human archeological bones for the first time, using rib bones from the Hitotsubashi site (AD 1657-1683) in Tokyo, called Edo in ancient times. The output data obtained were analysed using Gene Ontology and label-free quantification. We detected leucocyte-derived proteins, possibly originating from the bone marrow of the rib. Particularly prevalent and relatively high expression of eosinophil peroxidase suggests the influence of infectious diseases. This scenario is plausible, considering the overcrowding and unhygienic living conditions of the Edo city described in the historical literature. We also observed age-dependent differences in proteome profiles, particularly for proteins involved in developmental processes. Among them, alpha-2-HS-glycoprotein demonstrated a strong negative correlation with age. These results suggest that analysis of ancient proteins could provide a useful indicator of stress, disease, starvation, obesity and other kinds of physiological and pathological information.
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