ArticleFrontiers in pharmacology2017
Scopolamine Induces Deficits in Spontaneous Object-Location Recognition and Fear-Learning in Marmoset Monkeys.
Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 26 citations in OpenAlex.
- Pharmacological Insights intoMolecules (Basel, Switzerland) · 2026Review
- Home-cage pharmacology in marmosets: behavioral effects of scopolamine.Psychopharmacology · 2026Article
- Scopolamine induced learning deficit in marmosets.Research square · 2025Article
- Golden Oyster Mushroom Extract Ameliorates Oxidative Stress-Induced Cell Death in Neurons and Scopolamine-Induced Cholinergic System Impairment in Mice.Molecular neurobiology · 2025Article
- Scopolamine induced learning deficit in marmosets.bioRxiv : the preprint server for biology · 2025Article
- Comparative Physiology and Morphology of BLA-Projecting NBM/SI Cholinergic Neurons in Mouse and Macaque.The Journal of comparative neurology · 2024Article
- Comparative physiology and morphology of BLA-projecting NBM/SI cholinergic neurons in mouse and macaque.Research square · 2024Article
- A nonhuman primate model with Alzheimer's disease-like pathology induced by hippocampal overexpression of human tau.Alzheimer's research & therapy · 2024Article
- Induction of Anxiety-Like Phenotypes by Knockdown of Cannabinoid Type-1 Receptors in the Amygdala of Marmosets.Neuroscience bulletin · 2023Article
- Acetylcholine modulates the temporal dynamics of human theta oscillations during memory.Nature communications · 2023Article
- Spontaneous object recognition in capuchin monkeys: assessing the effects of sex, familiarization phase and retention delay.Animal cognition · 2023Article
- Emerging Electroencephalographic Biomarkers to Improve Preclinical to Clinical Translation in Alzheimer's Disease.Frontiers in aging neuroscience · 2022Review
- Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus).Scientific reports · 2021Article
- Current state of research on non-human primate models of Alzheimer's disease.Animal models and experimental medicine · 2019Review
- Aversive conditioning in the tardigrade, Dactylobiotus dispar.Journal of experimental psychology. Animal learning and cognition · 2019Article
- Neuropharmacological evaluation on four traditional herbs used as nervine tonic and commonly available as Shankhpushpi in India.Journal of Ayurveda and integrative medicineArticle
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The non-selective muscarinic receptor antagonist scopolamine (SCP) induces memory deficits in both animals and humans. However, few studies have assessed the effects of amnesic agents on memory functions of marmosets - a small-bodied neotropical primate that is becoming increasingly used as a translational model for several neuropathologies. Here we assessed the effects of an acute SCP administration (0.03 mg/kg, sc) on the behavior of adult marmoset monkeys in two tasks. In the spontaneous object-location (SOL) recognition task, two identical neutral stimuli were explored on the sample trial, after which preferential exploration of the displaced versus the stationary object was analyzed on the test trial. In the fear-motivated behavior (FMB) procedure, the same subjects were submitted to an initial baseline trial, followed by an exposure period to a snake model and lastly a post-exposure trial. All trials and inter-trial intervals lasted 10 min for both tests. Results showed that on the SOL test trial, the saline group explored the displaced object significantly longer than its identical stationary counterpart, whereas SCP-treated marmosets explored both objects equivalently. In the FMB test, the saline group - but not the SCP-treated animals - spent significantly less time where the stimulus had been specifically encountered and more time being vigilant of their surroundings, compared to pre-exposure levels. Drug-related effects on general activity, overall exploration (SOL task) and behavioral response to the aversive stimulus (FMB task) were not observed. SCP thus impaired the marmosets' short-term ability to detect changes associated with the spatial location of ethologically irrelevant (SOL task) and relevant stimuli (FMB task). Similar results have been reported in other animal species. Marmosets may thus help reduce the translational gap between pre-clinical studies and memory-associated human pathologies.
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