Evidence map›Paper›PMID 28680363›Full record

ArticleCancer cell international2017

Induction of apoptosis and proliferation inhibition of hepatocellular carcinoma by 6-chloro-2-methoxy-

Yun Huang, Guohua Liu, Feng Yang, Xiaowei Xing, Ying Li, Zhijun Huang, Hong Yuan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yun Huang *Center of Clinical Pharmacology, The Third Xiang Ya Hospital, Central South University, Changsha, 410013 China.
Guohua Liu *Center of Clinical Pharmacology, The Third Xiang Ya Hospital, Central South University, Changsha, 410013 China.
Feng YangCenter of Clinical Pharmacology, The Third Xiang Ya Hospital, Central South University, Changsha, 410013 China.
Xiaowei XingCenter of Clinical Pharmacology, The Third Xiang Ya Hospital, Central South University, Changsha, 410013 China.
Ying LiCenter of Clinical Pharmacology, The Third Xiang Ya Hospital, Central South University, Changsha, 410013 China.
Zhijun HuangCenter of Clinical Pharmacology, The Third Xiang Ya Hospital, Central South University, Changsha, 410013 China.
Hong YuanCenter of Clinical Pharmacology, The Third Xiang Ya Hospital, Central South University, Changsha, 410013 China.
Central South University · CNNational Medical Products Administration · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background6-Chloro-2-methoxy-

methodsIn this study, we investigated the anti-tumor effect of BA in human hepatocellular carcinoma (HCC) in vitro and in vivo using SMMC-7721 cells. The impact of BA on SMMC-7721 cells was determined by proliferation (clonogenicity and MTT), apoptosis (flow cytometry with annexin V-FITC labeling) and tumor cell migration (Transwell). Apoptosis-related molecules in the PI3K/AKT signaling pathway were examined via Western blotting. We also evaluated the effects of BA on tumor growth using a xenograft nude mouse model.

resultsThe data showed that BA induced dose-dependent cytotoxicity, anti-proliferation, anti-migration and apoptosis in SMMC-7721 cells, accompanied by activation of caspase-3 and a decreased level of caspase-9. Moreover, BA decreased PI3K and p-AKT levels, which indicated the cytotoxicity of BA through the PI3K/Akt pathway. Finally, we confirmed that BA inhibited tumor growth in an HCC xenograft mouse model.

conclusionsWe concluded that BA induced apoptosis and decreased PI3K and p-AKT expression in human HCC with no effect on the liver, kidney, spleen or lungs. These findings suggest that BA could provide a novel strategy for the treatment of HCC.

Indexed as

BAHepatocellular carcinomaPI3K/AktSponge

Identifiers

PMID28680363
PMCPMC5496258
OpenAlexW2727908163

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.