Evidence map›Paper›PMID 28680094›Full record

ArticleScientific reports2017

The importance of N-glycosylation on β

Xiulei Cai, Aye Myat Myat Thinn, Zhengli Wang, Hu Shan, Jieqing Zhu

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 71 citations in OpenAlex.

  1. Encoding Cell-Surface Receptor Function Through Glycosylation: Lessons From CD44.Chembiochem : a European journal of chemical biology · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. MnBiophysical journal · 2025
    Article
  9. Article
  10. Article
  11. Glycosylation in Cancer.Handbook of experimental pharmacology · 2025
    Review
  12. Review
  13. Metabolomics andCommunications biology · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. The glycosylation in SARS-CoV-2 and its receptor ACE2.Signal transduction and targeted therapy · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Xiulei CaiBlood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, 53226, USA.
Aye Myat Myat ThinnBlood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, 53226, USA.
Zhengli WangBlood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, 53226, USA.
Hu ShanCollege of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, China. shanhu67@163.com.
Jieqing ZhuBlood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, 53226, USA. Jieqing.Zhu@bcw.edu.
Medical College of Wisconsin · USVersiti Blood Center of Wisconsin · USQingdao Agricultural University · CN

Funding

Structural Transition of Cellular Integrins and Applications ThereofR01HL131836 · NHLBI · VERSITI WISCONSIN, INC. · PI Jieqing Zhu · 2016 to 2026
$5.5M
Conformational regulation in integrin bidirectional transmembrane signalingR56HL122985 · NHLBI · VERSITI WISCONSIN, INC. · PI ZHU, JIEQING · 2015 to 2015
$418k
NHLBI NIH HHS R01 HL131836NHLBI NIH HHS R56 HL122985
6 · The paper itself

Abstract

N-glycosylations can regulate the adhesive function of integrins. Great variations in both the number and distribution of N-glycosylation sites are found in the 18 α and 8 β integrin subunits. Crystal structures of α

Indexed as

Mutagenesis, Site-DirectedBinding SitesGlycosylationHEK293 CellsHumansIntegrin alphaVbeta3Integrin beta3LigandsMitochondrial ProteinsModels, MolecularPeptide Elongation Factor GPlatelet Glycoprotein GPIIb-IIIa ComplexPolysaccharidesProtein BindingProtein ConformationGFM1 protein, humanIntegrin alphaVbeta3Integrin beta3ITGB3 protein, humanLigandsMitochondrial ProteinsPeptide Elongation Factor GPlatelet Glycoprotein GPIIb-IIIa ComplexPolysaccharides

Identifiers

PMID28680094
PMCPMC5498496
OpenAlexW2727664948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.