ArticleScientific reports2017
Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Estrogen-immuno-neuromodulation disorders in menopausal depression.Journal of neuroinflammation · 2024Review
- Linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model.Scientific reports · 2024Article
- Ligand-Based Virtual Screening, Molecular Docking, and Molecular Dynamic Simulations of New β-Estrogen Receptor Activators with Potential for Pharmacological Obesity Treatment.Molecules (Basel, Switzerland) · 2023Article
- Menopause causes metabolic and cognitive impairments in a chronic cerebral hypoperfusion model of vascular contributions to cognitive impairment and dementia.Biology of sex differences · 2023Article
- Ovarian status modulates endocrine and neuroinflammatory responses to a murine mammary tumor.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Mitigating Effect of Estrogen in Alzheimer's Disease-Mimicking Cerebral Organoid.Frontiers in neuroscience · 2022Article
- Prolonged saturated, but not monounsaturated, high-fat feeding provokes anxiodepressive-like behaviors in female mice despite similar metabolic consequences.Brain, behavior, & immunity - health · 2021Article
- 1,3-Dicaffeoylquinic Acid as an Active Compound ofAntioxidants (Basel, Switzerland) · 2021Article
- Article
- Differential activation of Gsk-3β in the cortex and the hippocampus induces cognitive and behavioural impairments in middle-aged ovariectomized rat.Comprehensive psychoneuroendocrinology · 2020Article
- Effects of ERβ and ERα on OVX-induced changes in adiposity and insulin resistance.The Journal of endocrinology · 2020Article
- High-fat diet intake induces depressive-like behavior in ovariectomized rats.Scientific reports · 2019Article
- 17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity.Neurotoxicology · 2018Article
- Sex ModulatesFrontiers in microbiology · 2018Article
- Chemoprevention of LA7-Induced Mammary Tumor Growth by SM6Met, a Well-CharacterizedFrontiers in pharmacology · 2018Article
- Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ERβ activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor β-selective ligand (C-1) in ovariectomized mice. Uterine weight, depressive behaviour, and weight gain were examined in sham-operated control mice and ovariectomized mice administered placebo, C-1, or 17β-oestradiol (E2). Administration of C-1 or E2 reduced body weight gain and depressive-like behaviour in ovariectomized mice, as assessed by the forced swim test. In addition, administration of E2 to ovariectomized mice increased uterine weight, but administration of C-1 did not result in a significant increase in uterine weight. These results suggest that the selective activation of ERβ in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight. The present findings raise the possibility of the application of ERβ-ligands such as C-1 as a novel treatment for obesity and depression in postmenopausal women.
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