Evidence map›Paper›PMID 28680059›Full record

ArticleScientific reports2017

GWAS follow-up study of esophageal squamous cell carcinoma identifies potential genetic loci associated with family history of upper gastrointestinal cancer.

Xin Song, Wen-Qing Li, Nan Hu, Xue Ke Zhao, Zhaoming Wang, Paula L Hyland, Tao Jiang, Guo Qiang Kong, Hua Su, Chaoyu Wang and 27 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
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  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 10 institutions in 2 countries.

Xin SongHenan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan, 450052, P.R. China.
Wen-Qing LiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Nan HuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Xue Ke ZhaoHenan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan, 450052, P.R. China.
Zhaoming WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Paula L HylandDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Tao JiangHenan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan, 450052, P.R. China.
Guo Qiang KongHenan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan, 450052, P.R. China.
Hua SuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Chaoyu WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Lemin WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Li SunHenan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan, 450052, P.R. China.
Zong Min FanHenan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan, 450052, P.R. China.
Hui MengHenan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan, 450052, P.R. China.
Tang Juan ZhangHenan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan, 450052, P.R. China.
Ling Fen JiHenan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan, 450052, P.R. China.
Shou Jia HuHenan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan, 450052, P.R. China.
Wei Li HanHenan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan, 450052, P.R. China.
Min Jie WuDepartment of Gastroenterology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan province, 450052, China.
Peng Yuan ZhengDepartment of Gastroenterology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan province, 450052, China.
Shuang LvDepartment of Gastroenterology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan province, 450052, China.
Xue Min LiDepartment of Pathology, Cixian Hospital, Cixian, Hebei, 056500, P.R. China.
Fu You ZhouDepartment of Thoracic Surgery, Anyang Tumor Hospital, Anyang, Henan, 455000, P.R. China.
Laurie BurdettDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Ti DingShanxi Cancer Hospital, Taiyuan, Shanxi, P.R. China.
You-Lin QiaoDepartment of Epidemiology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, P.R. China.ORCID 0000-0001-6380-0871
Jin-Hu FanDepartment of Epidemiology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, P.R. China.
Xiao-You HanShanxi Cancer Hospital, Taiyuan, Shanxi, P.R. China.
Carol GiffenInformation Management Services, Inc., Silver Spring, MD, USA.
Margaret A TuckerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Sanford M DawseyDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Christian C AbnetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.ORCID 0000-0002-3008-7843
Philip R TaylorDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Li-Dong WangHenan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan, 450052, P.R. China. ldwang2007@126.com.
Alisa M GoldsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA. goldstea@mail.nih.gov.
National Cancer Institute · USFirst Affiliated Hospital of Zhengzhou University · CNFifth Affiliated Hospital of Zhengzhou University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNLeidos (United States) · USShanxi Provincial Cancer Hospital · CNAnyang Tumor Hospital · CNBrown University · USCixian People's Hospital · CNInformation Management Services · US

Funding

Esophageal cancer genetic projectZIACP010224 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GOLDSTEIN, ALISA · 2012 to 2025
$7.3M
6 · The paper itself

Abstract

Based on our initial genome-wide association study (GWAS) on esophageal squamous cell carcinoma (ESCC) in Han Chinese, we conducted a follow-up study to examine the single nucleotide polymorphisms (SNPs) associated with family history (FH) of upper gastrointestinal cancer (UGI) cancer in cases with ESCC. We evaluated the association between SNPs and FH of UGI cancer among ESCC cases in a stage-1 case-only analysis of the National Cancer Institute (NCI, 541 cases with FH and 1399 without FH) and Henan GWAS (493 cases with FH and 869 without FH) data (discovery phase). The top SNPs (or their surrogates) from discovery were advanced to a stage-2 evaluation in additional Henan subjects (2801 cases with FH and 3136 without FH, replication phase). A total of 19 SNPs were associated with FH of UGI cancer in ESCC cases with P < 10

Indexed as

Polymorphism, Single NucleotideAsian PeopleChinaEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleFollow-Up StudiesGastrointestinal NeoplasmsGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleNeoplasm Staging

Identifiers

PMID28680059
PMCPMC5498542
OpenAlexW2731287810

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.