Evidence map›Paper›PMID 28680050›Full record

ArticleScientific reports2017

Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization.

Sreenivas Gannavaram, John Torcivia, Lusine Gasparyan, Amit Kaul, Nevien Ismail, Vahan Simonyan, Hira L Nakhasi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Targeted Deletion of Centrin inFrontiers in cellular and infection microbiology · 2021
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sreenivas GannavaramDivision of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 20993, USA. sreenivas.gannavaram@fda.hhs.gov.
John TorciviaHigh Performance Integrated Virtual Environment, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 20993, USA.
Lusine GasparyanDNA-HIVE, Rockville, 20850, MD, United States.
Amit KaulDivision of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 20993, USA.
Nevien IsmailDivision of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 20993, USA.
Vahan SimonyanHigh Performance Integrated Virtual Environment, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 20993, USA. vahan.simonyan@fda.hhs.gov.
Hira L NakhasiDivision of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, 20993, USA. hira.nakhasi@fda.hhs.gov.
Center for Biologics Evaluation and Research · USUnited States Food and Drug Administration · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

No licensed human vaccines are currently available against leishmaniasis. Several anti-leishmanial vaccines are currently undergoing testing, including genetically modified live-attenuated parasite vaccines. Studies with live attenuated Leishmania vaccines such as centrin deleted Leishmania donovani parasites (LdCen

Indexed as

Computational BiologyGenetic MarkersGenome, ProtozoanHumansLeishmania donovaniProtozoan VaccinesSequence DeletionVaccines, AttenuatedWhole Genome SequencingGenetic MarkersProtozoan VaccinesVaccines, Attenuated

Identifiers

PMID28680050
PMCPMC5498541
OpenAlexW2729683236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.