Evidence map›Paper›PMID 28679779›Full record

ArticleMolecular cancer research : MCR2017

Molecular Effects of Stromal-Selective Targeting by uPAR-Retargeted Oncolytic Virus in Breast Cancer.

Yuqi Jing, Valery Chavez, Yuguang Ban, Nicolas Acquavella, Doraya El-Ashry, Alexey Pronin, Xi Chen, Jaime R Merchan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer research : MCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
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  4. Profibrinolytic Factors and Cancer Progression, Metastasis, and Survival.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
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  9. Article
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  12. Synergism of rMV-Hu191 with cisplatin to treat gastric cancer by acid sphingomyelinase-mediated apoptosis requiring integrity of lipid raft microdomains.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021
    Article
  13. Review
  14. Review
  15. Beyond cancer cells: Targeting the tumor microenvironment with gene therapy and armed oncolytic virus.Molecular therapy : the journal of the American Society of Gene Therapy · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yuqi JingDivision of Hematology-Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.
Valery ChavezDivision of Hematology-Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.
Yuguang BanDivision of Biostatistics and Bioinformatics, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.
Nicolas AcquavellaDivision of Hematology-Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.
Doraya El-AshryDivision of Hematology-Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.
Alexey ProninDepartment of Molecular & Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida.
Xi ChenDivision of Biostatistics and Bioinformatics, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.
Jaime R MerchanDivision of Hematology-Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida. jmerchan2@med.miami.edu.
Sylvester Comprehensive Cancer Center · USUniversity of Miami · US

Funding

Tumor and Stromal Targeting by Oncolytic VirusesR01CA149659 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MERCHAN, JAIME R · 2011 to 2015
$1.7M
NCI NIH HHS R01 CA149659
6 · The paper itself

Abstract

The tumor microenvironment (TME) is a relevant target for novel biological therapies. MV-m-uPA and MV-h-uPA are fully retargeted, species-specific, oncolytic measles viruses (MV) directed against murine or human urokinase receptor (PLAUR/uPAR), expressed in tumor and stromal cells. The effects of stromal-selective targeting by uPAR-retargeted MVs were investigated.

Indexed as

AnimalsBreast NeoplasmsCancer-Associated FibroblastsCell Line, TumorCell ProliferationCoculture TechniquesFemaleHT29 CellsHumansMeasles virusMiceOncolytic VirotherapyOncolytic VirusesReceptors, Urokinase Plasminogen ActivatorStromal CellsTumor MicroenvironmentPLAUR protein, humanReceptors, Urokinase Plasminogen Activator

Identifiers

PMID28679779
PMCPMC5682105
OpenAlexW2734284893

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.